Metabolic activation of o-phenylphenol to a major cytotoxic metabolite, phenylhydroquinone: role of human CYP1A2 and rat CYP2C11/CYP2E1.

Ozawa, S

Metabolic activation of o-phenylphenol to a major cytotoxic metabolite, phenylhydroquinone: role of human CYP1A2 and rat CYP2C11/CYP2E1. [electronic resource] - Xenobiotica; the fate of foreign compounds in biological systems Oct 2000 - 1005-17 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0049-8254

10.1080/00498250050200159 doi


Animals
Aryl Hydrocarbon Hydroxylases
Biotransformation
Biphenyl Compounds--pharmacokinetics
Cytochrome P-450 CYP1A2--metabolism
Cytochrome P-450 CYP2E1--metabolism
Cytochrome P-450 Enzyme System--metabolism
Cytochrome P450 Family 2
Cytochromes
Flavonoids
Humans
Hydroquinones--pharmacokinetics
Hydroxylation
Isoenzymes--metabolism
Kinetics
Liver Neoplasms, Experimental
Male
Microsomes, Liver--enzymology
Phenols--pharmacokinetics
Polymers--pharmacokinetics
Polyphenols
Rats
Rats, Inbred F344
Rats, Sprague-Dawley
Recombinant Proteins--metabolism
Steroid 16-alpha-Hydroxylase
Steroid Hydroxylases--metabolism
Tumor Cells, Cultured