Increased resistance to anticancer therapy of mouse cells lacking the poly(ADP-ribose) polymerase attributable to up-regulation of the multidrug resistance gene product P-glycoprotein. [electronic resource]
Producer: 20000831Description: 4238-44 p. digitalISSN:- 0008-5472
- ATP Binding Cassette Transporter, Subfamily B, Member 1 -- antagonists & inhibitors
- Animals
- Antineoplastic Agents -- pharmacokinetics
- Breast Neoplasms -- drug therapy
- Clone Cells
- Dose-Response Relationship, Drug
- Doxorubicin -- pharmacokinetics
- Drug Resistance, Multiple -- genetics
- Drug Resistance, Neoplasm -- genetics
- Embryo, Mammalian
- Fibroblasts -- drug effects
- Gene Expression Regulation -- drug effects
- Gene Expression Regulation, Neoplastic
- Humans
- Mice
- Mice, Knockout
- Poly(ADP-ribose) Polymerases -- deficiency
- Probenecid -- pharmacology
- Tumor Cells, Cultured
- Tumor Suppressor Protein p53 -- biosynthesis
- Up-Regulation
- Verapamil -- pharmacology
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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