Increased resistance to anticancer therapy of mouse cells lacking the poly(ADP-ribose) polymerase attributable to up-regulation of the multidrug resistance gene product P-glycoprotein.

Wurzer, G

Increased resistance to anticancer therapy of mouse cells lacking the poly(ADP-ribose) polymerase attributable to up-regulation of the multidrug resistance gene product P-glycoprotein. [electronic resource] - Cancer research Aug 2000 - 4238-44 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0008-5472


ATP Binding Cassette Transporter, Subfamily B, Member 1--antagonists & inhibitors
Animals
Antineoplastic Agents--pharmacokinetics
Breast Neoplasms--drug therapy
Clone Cells
Dose-Response Relationship, Drug
Doxorubicin--pharmacokinetics
Drug Resistance, Multiple--genetics
Drug Resistance, Neoplasm--genetics
Embryo, Mammalian
Fibroblasts--drug effects
Gene Expression Regulation--drug effects
Gene Expression Regulation, Neoplastic
Humans
Mice
Mice, Knockout
Poly(ADP-ribose) Polymerases--deficiency
Probenecid--pharmacology
Tumor Cells, Cultured
Tumor Suppressor Protein p53--biosynthesis
Up-Regulation
Verapamil--pharmacology