EC3, a heterodimeric disintegrin from Echis carinatus, inhibits human and murine alpha4 integrin and attenuates lymphocyte infiltration of Langerhans islets in pancreas and salivary glands in nonobese diabetic mice. [electronic resource]
Producer: 20000208Description: 413-7 p. digitalISSN:- 0006-291X
- Amino Acid Sequence
- Animals
- Antigens, CD -- drug effects
- Cell Adhesion
- Diabetes Mellitus, Type 1 -- immunology
- Disintegrins -- chemistry
- Humans
- Integrin alpha4
- Intercellular Signaling Peptides and Proteins
- Islets of Langerhans -- immunology
- Jurkat Cells
- Lymphocytes -- drug effects
- Mice
- Mice, Inbred NOD
- Molecular Sequence Data
- Peptides -- chemistry
- Salivary Glands -- immunology
- Sequence Alignment
- Sequence Homology, Amino Acid
- Spleen -- immunology
- Tumor Cells, Cultured
- Viper Venoms -- chemistry
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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