EC3, a heterodimeric disintegrin from Echis carinatus, inhibits human and murine alpha4 integrin and attenuates lymphocyte infiltration of Langerhans islets in pancreas and salivary glands in nonobese diabetic mice.

Brando, C

EC3, a heterodimeric disintegrin from Echis carinatus, inhibits human and murine alpha4 integrin and attenuates lymphocyte infiltration of Langerhans islets in pancreas and salivary glands in nonobese diabetic mice. [electronic resource] - Biochemical and biophysical research communications Jan 2000 - 413-7 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

0006-291X

10.1006/bbrc.1999.1897 doi


Amino Acid Sequence
Animals
Antigens, CD--drug effects
Cell Adhesion
Diabetes Mellitus, Type 1--immunology
Disintegrins--chemistry
Humans
Integrin alpha4
Intercellular Signaling Peptides and Proteins
Islets of Langerhans--immunology
Jurkat Cells
Lymphocytes--drug effects
Mice
Mice, Inbred NOD
Molecular Sequence Data
Peptides--chemistry
Salivary Glands--immunology
Sequence Alignment
Sequence Homology, Amino Acid
Spleen--immunology
Tumor Cells, Cultured
Viper Venoms--chemistry