000 02389 a2200685 4500
005 20250513154412.0
264 0 _c19981221
008 199812s 0 0 eng d
022 _a0006-4971
040 _aNLM
_beng
_cNLM
100 1 _aByrd, J C
245 0 0 _aFlavopiridol induces apoptosis in chronic lymphocytic leukemia cells via activation of caspase-3 without evidence of bcl-2 modulation or dependence on functional p53.
_h[electronic resource]
260 _bBlood
_cNov 1998
300 _a3804-16 p.
_bdigital
500 _aPublication Type: Journal Article
650 0 4 _aAnimals
650 0 4 _aAntineoplastic Agents
_xadministration & dosage
650 0 4 _aApoptosis
_xdrug effects
650 0 4 _aCaspase 3
650 0 4 _aCaspases
_xphysiology
650 0 4 _aCell Cycle Proteins
650 0 4 _aChromosomes, Human, Pair 17
_xgenetics
650 0 4 _aCyclin-Dependent Kinase Inhibitor p27
650 0 4 _aDrug Administration Schedule
650 0 4 _aDrug Resistance, Neoplasm
650 0 4 _aDrug Screening Assays, Antitumor
650 0 4 _aEnzyme Activation
_xdrug effects
650 0 4 _aEnzyme Precursors
_xmetabolism
650 0 4 _aFlavonoids
_xadministration & dosage
650 0 4 _aGene Deletion
650 0 4 _aGenes, p53
650 0 4 _aGrowth Inhibitors
_xadministration & dosage
650 0 4 _aHumans
650 0 4 _aIn Situ Hybridization, Fluorescence
650 0 4 _aInterleukin-4
_xpharmacology
650 0 4 _aLeukemia, Lymphocytic, Chronic, B-Cell
_xdrug therapy
650 0 4 _aMice
650 0 4 _aMice, Inbred C57BL
650 0 4 _aMice, Knockout
650 0 4 _aMicrotubule-Associated Proteins
_xbiosynthesis
650 0 4 _aNeoplasm Proteins
_xbiosynthesis
650 0 4 _aPiperidines
_xadministration & dosage
650 0 4 _aProto-Oncogene Proteins
_xbiosynthesis
650 0 4 _aProto-Oncogene Proteins c-bcl-2
_xbiosynthesis
650 0 4 _aTumor Cells, Cultured
650 0 4 _aTumor Suppressor Protein p53
_xphysiology
650 0 4 _aTumor Suppressor Proteins
650 0 4 _aVidarabine
_xanalogs & derivatives
650 0 4 _abcl-2-Associated X Protein
700 1 _aShinn, C
700 1 _aWaselenko, J K
700 1 _aFuchs, E J
700 1 _aLehman, T A
700 1 _aNguyen, P L
700 1 _aFlinn, I W
700 1 _aDiehl, L F
700 1 _aSausville, E
700 1 _aGrever, M R
773 0 _tBlood
_gvol. 92
_gno. 10
_gp. 3804-16
999 _c9772922
_d9772922