| 000 | 01804 a2200493 4500 | ||
|---|---|---|---|
| 005 | 20250513151920.0 | ||
| 264 | 0 | _c19981007 | |
| 008 | 199810s 0 0 eng d | ||
| 022 | _a0003-9861 | ||
| 024 | 7 |
_a10.1006/abbi.1998.0826 _2doi |
|
| 040 |
_aNLM _beng _cNLM |
||
| 100 | 1 | _aKlose, T S | |
| 245 | 0 | 0 |
_aIdentification of residues 286 and 289 as critical for conferring substrate specificity of human CYP2C9 for diclofenac and ibuprofen. _h[electronic resource] |
| 260 |
_bArchives of biochemistry and biophysics _cSep 1998 |
||
| 300 |
_a240-8 p. _bdigital |
||
| 500 | _aPublication Type: Journal Article | ||
| 650 | 0 | 4 | _aAryl Hydrocarbon Hydroxylases |
| 650 | 0 | 4 | _aCytochrome P-450 CYP2C19 |
| 650 | 0 | 4 | _aCytochrome P-450 CYP2C9 |
| 650 | 0 | 4 | _aCytochrome P-450 Enzyme Inhibitors |
| 650 | 0 | 4 |
_aCytochrome P-450 Enzyme System _xgenetics |
| 650 | 0 | 4 |
_aDiclofenac _xmetabolism |
| 650 | 0 | 4 |
_aEnzyme Activation _xdrug effects |
| 650 | 0 | 4 |
_aEscherichia coli _xgenetics |
| 650 | 0 | 4 | _aHumans |
| 650 | 0 | 4 | _aHydroxylation |
| 650 | 0 | 4 |
_aIbuprofen _xmetabolism |
| 650 | 0 | 4 |
_aMixed Function Oxygenases _xgenetics |
| 650 | 0 | 4 | _aMutagenesis, Site-Directed |
| 650 | 0 | 4 |
_aProtein Binding _xdrug effects |
| 650 | 0 | 4 |
_aRecombinant Fusion Proteins _xgenetics |
| 650 | 0 | 4 | _aSteroid 16-alpha-Hydroxylase |
| 650 | 0 | 4 |
_aSteroid Hydroxylases _xantagonists & inhibitors |
| 650 | 0 | 4 |
_aSubstrate Specificity _xgenetics |
| 650 | 0 | 4 |
_aTolbutamide _xmetabolism |
| 700 | 1 | _aIbeanu, G C | |
| 700 | 1 | _aGhanayem, B I | |
| 700 | 1 | _aPedersen, L G | |
| 700 | 1 | _aLi, L | |
| 700 | 1 | _aHall, S D | |
| 700 | 1 | _aGoldstein, J A | |
| 773 | 0 |
_tArchives of biochemistry and biophysics _gvol. 357 _gno. 2 _gp. 240-8 |
|
| 856 | 4 | 0 |
_uhttps://doi.org/10.1006/abbi.1998.0826 _zAvailable from publisher's website |
| 999 |
_c9700248 _d9700248 |
||