000 02186 a2200685 4500
005 20250513145010.0
264 0 _c19980724
008 199807s 0 0 eng d
022 _a0022-2623
024 7 _a10.1021/jm960683m
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aTecle, H
245 0 0 _aDesign and synthesis of m1-selective muscarinic agonists: (R)-(-)-(Z)-1-Azabicyclo[2.2.1]heptan-3-one, O-(3-(3'-methoxyphenyl)-2-propynyl)oxime maleate (CI-1017), a functionally m1-selective muscarinic agonist.
_h[electronic resource]
260 _bJournal of medicinal chemistry
_cJul 1998
300 _a2524-36 p.
_bdigital
500 _aPublication Type: Journal Article
650 0 4 _a3T3 Cells
650 0 4 _aAdenylyl Cyclase Inhibitors
650 0 4 _aAnimals
650 0 4 _aBridged Bicyclo Compounds, Heterocyclic
_xchemical synthesis
650 0 4 _aCHO Cells
650 0 4 _aCricetinae
650 0 4 _aDrug Design
650 0 4 _aEnzyme Inhibitors
_xchemical synthesis
650 0 4 _aHumans
650 0 4 _aInositol Phosphates
_xbiosynthesis
650 0 4 _aMale
650 0 4 _aMemory
_xdrug effects
650 0 4 _aMice
650 0 4 _aMuscarinic Agonists
_xchemical synthesis
650 0 4 _aOximes
_xchemical synthesis
650 0 4 _aRats
650 0 4 _aReceptor, Muscarinic M1
650 0 4 _aReceptors, Muscarinic
_xdrug effects
650 0 4 _aStereoisomerism
650 0 4 _aStructure-Activity Relationship
650 0 4 _aTransfection
700 1 _aBarrett, S D
700 1 _aLauffer, D J
700 1 _aAugelli-Szafran, C
700 1 _aBrann, M R
700 1 _aCallahan, M J
700 1 _aCaprathe, B W
700 1 _aDavis, R E
700 1 _aDoyle, P D
700 1 _aEubanks, D
700 1 _aLipiniski, W
700 1 _aMirzadegan, T
700 1 _aMoos, W H
700 1 _aMoreland, D W
700 1 _aNelson, C B
700 1 _aPavia, M R
700 1 _aRaby, C
700 1 _aSchwarz, R D
700 1 _aSpencer, C J
700 1 _aThomas, A J
700 1 _aJaen, J C
773 0 _tJournal of medicinal chemistry
_gvol. 41
_gno. 14
_gp. 2524-36
856 4 0 _uhttps://doi.org/10.1021/jm960683m
_zAvailable from publisher's website
999 _c9617283
_d9617283