000 02046 a2200613 4500
005 20250513132243.0
264 0 _c19980112
008 199801s 0 0 eng d
022 _a0022-2623
024 7 _a10.1021/jm970517u
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aSelnick, H G
245 0 0 _aClass III antiarrhythmic activity in vivo by selective blockade of the slowly activating cardiac delayed rectifier potassium current IKs by (R)-2-(2,4-trifluoromethyl)-N-[2-oxo-5-phenyl-1-(2,2,2-trifluoroethyl)- 2, 3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]acetamide.
_h[electronic resource]
260 _bJournal of medicinal chemistry
_cNov 1997
300 _a3865-8 p.
_bdigital
500 _aPublication Type: Journal Article
650 0 4 _aAcetamides
_xchemical synthesis
650 0 4 _aAdministration, Oral
650 0 4 _aAnimals
650 0 4 _aAnti-Arrhythmia Agents
_xchemical synthesis
650 0 4 _aBenzodiazepinones
_xchemical synthesis
650 0 4 _aCells, Cultured
650 0 4 _aDogs
650 0 4 _aElectrocardiography, Ambulatory
_xdrug effects
650 0 4 _aGuinea Pigs
650 0 4 _aHeart
_xdrug effects
650 0 4 _aHumans
650 0 4 _aMyocardium
_xcytology
650 0 4 _aPotassium Channel Blockers
650 0 4 _aPotassium Channels
_xphysiology
650 0 4 _aXenopus
700 1 _aLiverton, N J
700 1 _aBaldwin, J J
700 1 _aButcher, J W
700 1 _aClaremon, D A
700 1 _aElliott, J M
700 1 _aFreidinger, R M
700 1 _aKing, S A
700 1 _aLibby, B E
700 1 _aMcIntyre, C J
700 1 _aPribush, D A
700 1 _aRemy, D C
700 1 _aSmith, G R
700 1 _aTebben, A J
700 1 _aJurkiewicz, N K
700 1 _aLynch, J J
700 1 _aSalata, J J
700 1 _aSanguinetti, M C
700 1 _aSiegl, P K
700 1 _aSlaughter, D E
700 1 _aVyas, K
773 0 _tJournal of medicinal chemistry
_gvol. 40
_gno. 24
_gp. 3865-8
856 4 0 _uhttps://doi.org/10.1021/jm970517u
_zAvailable from publisher's website
999 _c9366851
_d9366851