000			02186 a2200685 4500
005			20250513125638.0
264		0	_c19971230
008			199712s 0 0 eng d
022			_a0065-2598
040			_aNLM _beng _cNLM
100	1		_aLau, C K
245	0	0	_aFrom indomethacin to a selective COX-2 inhibitor. Development of indolalkanoic acids as potent and selective cyclooxygenase-2 inhibitors. _h[electronic resource]
260			_bAdvances in experimental medicine and biology _c1997
300			_a73-8 p. _bdigital
500			_aPublication Type: Comparative Study; Journal Article
650	0	4	_aAnimals
650	0	4	_aAnti-Inflammatory Agents, Non-Steroidal _xchemical synthesis
650	0	4	_aCarrageenan _xtoxicity
650	0	4	_aChromium Radioisotopes
650	0	4	_aCyclooxygenase 1
650	0	4	_aCyclooxygenase 2
650	0	4	_aCyclooxygenase 2 Inhibitors
650	0	4	_aCyclooxygenase Inhibitors _xchemical synthesis
650	0	4	_aDigestive System _xdrug effects
650	0	4	_aEdema _xchemically induced
650	0	4	_aFeces _xchemistry
650	0	4	_aFever _xchemically induced
650	0	4	_aIndomethacin _xanalogs & derivatives
650	0	4	_aIsoenzymes _xdrug effects
650	0	4	_aMembrane Proteins
650	0	4	_aMolecular Conformation
650	0	4	_aMolecular Structure
650	0	4	_aNeoplasm Proteins _xantagonists & inhibitors
650	0	4	_aProstaglandin-Endoperoxide Synthases _xdrug effects
650	0	4	_aRats
650	0	4	_aStructure-Activity Relationship
650	0	4	_aSubstrate Specificity
650	0	4	_aTumor Cells, Cultured
700	1		_aBlack, W C
700	1		_aBelley, M
700	1		_aChan, C
700	1		_aCharleson, S
700	1		_aDenis, D
700	1		_aGauthier, J Y
700	1		_aGordon, R
700	1		_aGuay, D
700	1		_aHamel, P
700	1		_aKargman, S
700	1		_aLeblanc, Y
700	1		_aMancini, J
700	1		_aOuellet, M
700	1		_aPercival, D
700	1		_aPrasit, P
700	1		_aRoy, P
700	1		_aSkorey, K
700	1		_aTagari, P
700	1		_aVickers, P
700	1		_aWong, E
773	0		_tAdvances in experimental medicine and biology _gvol. 407 _gp. 73-8
999			_c9295585 _d9295585