000 01663 a2200445 4500
005 20250513113745.0
264 0 _c19970417
008 199704s 0 0 eng d
022 _a0007-0920
024 7 _a10.1038/bjc.1997.176
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aDesiderio, M A
245 0 0 _aTreatment with inhibitors of polyamine biosynthesis, which selectively lower intracellular spermine, does not affect the activity of alkylating agents but antagonizes the cytotoxicity of DNA topoisomerase II inhibitors.
_h[electronic resource]
260 _bBritish journal of cancer
_c1997
300 _a1028-34 p.
_bdigital
500 _aPublication Type: Journal Article; Research Support, Non-U.S. Gov't
650 0 4 _aAlkynes
650 0 4 _aAntineoplastic Agents, Alkylating
_xpharmacology
650 0 4 _aCell Cycle
_xdrug effects
650 0 4 _aCell Survival
_xdrug effects
650 0 4 _aDNA, Neoplasm
_xbiosynthesis
650 0 4 _aDeoxyadenosines
_xpharmacology
650 0 4 _aDiamines
_xpharmacology
650 0 4 _aEnzyme Inhibitors
_xpharmacology
650 0 4 _aFemale
650 0 4 _aHumans
650 0 4 _aOrnithine Decarboxylase Inhibitors
650 0 4 _aOvarian Neoplasms
650 0 4 _aPolyamines
_xmetabolism
650 0 4 _aSpermine
_xmetabolism
650 0 4 _aTopoisomerase II Inhibitors
650 0 4 _aTumor Cells, Cultured
700 1 _aBergamaschi, D
700 1 _aMascellani, E
700 1 _aDe Feudis, P
700 1 _aErba, E
700 1 _aD'Incalci, M
773 0 _tBritish journal of cancer
_gvol. 75
_gno. 7
_gp. 1028-34
856 4 0 _uhttps://doi.org/10.1038/bjc.1997.176
_zAvailable from publisher's website
999 _c9068052
_d9068052