000			02218 a2200697 4500
005			20250513112955.0
264		0	_c19970417
008			199704s 0 0 eng d
022			_a0022-2623
024	7		_a10.1021/jm960613f _2doi
040			_aNLM _beng _cNLM
100	1		_aJones, T R
245	0	0	_aStructure-based design of substituted diphenyl sulfones and sulfoxides as lipophilic inhibitors of thymidylate synthase. _h[electronic resource]
260			_bJournal of medicinal chemistry _cFeb 1997
300			_a677-83 p. _bdigital
500			_aPublication Type: Journal Article
650	0	4	_aAnimals
650	0	4	_aAntineoplastic Agents _xchemical synthesis
650	0	4	_aCell Division _xdrug effects
650	0	4	_aCrystallography, X-Ray
650	0	4	_aDrug Screening Assays, Antitumor
650	0	4	_aEnzyme Inhibitors _xchemical synthesis
650	0	4	_aEscherichia coli _xenzymology
650	0	4	_aHumans
650	0	4	_aMagnetic Resonance Spectroscopy
650	0	4	_aMice
650	0	4	_aModels, Molecular
650	0	4	_aMolecular Conformation
650	0	4	_aMolecular Structure
650	0	4	_aNeoplasms, Experimental _xdrug therapy
650	0	4	_aQuinazolines _xchemical synthesis
650	0	4	_aStructure-Activity Relationship
650	0	4	_aSulfones _xchemical synthesis
650	0	4	_aSulfoxides _xchemical synthesis
650	0	4	_aThymidylate Synthase _xantagonists & inhibitors
650	0	4	_aTumor Cells, Cultured
700	1		_aWebber, S E
700	1		_aVarney, M D
700	1		_aReddy, M R
700	1		_aLewis, K K
700	1		_aKathardekar, V
700	1		_aMazdiyasni, H
700	1		_aDeal, J
700	1		_aNguyen, D
700	1		_aWelsh, K M
700	1		_aWebber, S
700	1		_aJohnston, A
700	1		_aMatthews, D A
700	1		_aSmith, W W
700	1		_aJanson, C A
700	1		_aBacquet, R J
700	1		_aHowland, E F
700	1		_aBooth, C L
700	1		_aHerrmann, S M
700	1		_aWard, R W
700	1		_aWhite, J
700	1		_aBartlett, C A
700	1		_aMorse, C A
773	0		_tJournal of medicinal chemistry _gvol. 40 _gno. 5 _gp. 677-83
856	4	0	_uhttps://doi.org/10.1021/jm960613f _zAvailable from publisher's website
999			_c9045898 _d9045898