000 01286 a2200373 4500
005 20250513100600.0
264 0 _c19970204
008 199702s 0 0 eng d
022 _a1074-5521
024 7 _a10.1016/s1074-5521(96)90108-8
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aHung, D T
245 0 0 _a(+)-Discodermolide binds to microtubules in stoichiometric ratio to tubulin dimers, blocks taxol binding and results in mitotic arrest.
_h[electronic resource]
260 _bChemistry & biology
_cApr 1996
300 _a287-93 p.
_bdigital
500 _aPublication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
650 0 4 _a3T3 Cells
650 0 4 _aAlkanes
650 0 4 _aAnimals
650 0 4 _aBinding Sites
650 0 4 _aCarbamates
650 0 4 _aCell Line
650 0 4 _aHumans
650 0 4 _aLactones
_xmetabolism
650 0 4 _aMice
650 0 4 _aMicrotubules
_xmetabolism
650 0 4 _aMitosis
_xdrug effects
650 0 4 _aPaclitaxel
_xantagonists & inhibitors
650 0 4 _aPyrones
700 1 _aChen, J
700 1 _aSchreiber, S L
773 0 _tChemistry & biology
_gvol. 3
_gno. 4
_gp. 287-93
856 4 0 _uhttps://doi.org/10.1016/s1074-5521(96)90108-8
_zAvailable from publisher's website
999 _c8802556
_d8802556