000			01957 a2200553 4500
005			20250513100516.0
264		0	_c19961209
008			199612s 0 0 eng d
022			_a0969-2126
024	7		_a10.1016/s0969-2126(96)00098-6 _2doi
040			_aNLM _beng _cNLM
100	1		_aBreton, R
245	0	0	_aThe structure of a complex of human 17beta-hydroxysteroid dehydrogenase with estradiol and NADP+ identifies two principal targets for the design of inhibitors. _h[electronic resource]
260			_bStructure (London, England : 1993) _cAug 1996
300			_a905-15 p. _bdigital
500			_aPublication Type: Journal Article; Research Support, Non-U.S. Gov't
650	0	4	_aAmino Acid Sequence
650	0	4	_aAntineoplastic Agents _xchemistry
650	0	4	_aBinding Sites _xdrug effects
650	0	4	_aCatalysis
650	0	4	_aCrystallography, X-Ray
650	0	4	_aDrug Design
650	0	4	_aEnzyme Inhibitors _xchemistry
650	0	4	_aEstradiol _xchemistry
650	0	4	_aEstradiol Dehydrogenases _xantagonists & inhibitors
650	0	4	_aEstrone _xmetabolism
650	0	4	_aFemale
650	0	4	_aHumans
650	0	4	_aMacromolecular Substances
650	0	4	_aModels, Molecular
650	0	4	_aMolecular Conformation
650	0	4	_aMolecular Sequence Data
650	0	4	_aNADP _xchemistry
650	0	4	_aOxidation-Reduction
650	0	4	_aOxygen _xchemistry
650	0	4	_aPlacenta _xenzymology
650	0	4	_aProtein Binding _xdrug effects
650	0	4	_aProtein Conformation
650	0	4	_aRecombinant Proteins _xchemistry
650	0	4	_aSerine _xchemistry
650	0	4	_aSubstrate Specificity
650	0	4	_aTemperature
650	0	4	_aTyrosine _xchemistry
700	1		_aHousset, D
700	1		_aMazza, C
700	1		_aFontecilla-Camps, J C
773	0		_tStructure (London, England : 1993) _gvol. 4 _gno. 8 _gp. 905-15
856	4	0	_uhttps://doi.org/10.1016/s0969-2126(96)00098-6 _zAvailable from publisher's website
999			_c8800288 _d8800288