000			02386 a2200769 4500
005			20250513084651.0
264		0	_c19960301
008			199603s 0 0 eng d
022			_a0022-2623
024	7		_a10.1021/jm950642a _2doi
040			_aNLM _beng _cNLM
100	1		_aLeftheris, K
245	0	0	_aDevelopment of highly potent inhibitors of Ras farnesyltransferase possessing cellular and in vivo activity. _h[electronic resource]
260			_bJournal of medicinal chemistry _cJan 1996
300			_a224-36 p. _bdigital
500			_aPublication Type: Journal Article
650	0	4	_a3T3 Cells
650	0	4	_aAlkyl and Aryl Transferases
650	0	4	_aAnimals
650	0	4	_aAntineoplastic Agents _xchemical synthesis
650	0	4	_aBrain _xenzymology
650	0	4	_aCell Division _xdrug effects
650	0	4	_aCell Line, Transformed
650	0	4	_aCell Transformation, Neoplastic _xdrug effects
650	0	4	_aDrug Design
650	0	4	_aEnzyme Inhibitors _xchemical synthesis
650	0	4	_aGenes, ras _xgenetics
650	0	4	_aGlutamates _xchemical synthesis
650	0	4	_aIsoquinolines _xchemical synthesis
650	0	4	_aMethionine _xanalogs & derivatives
650	0	4	_aMice
650	0	4	_aMice, Nude
650	0	4	_aMolecular Structure
650	0	4	_aNeoplasm Transplantation
650	0	4	_aOncogene Protein p21(ras) _xmetabolism
650	0	4	_aProtein Prenylation _xdrug effects
650	0	4	_aRats
650	0	4	_aSwine
650	0	4	_aTetrahydroisoquinolines
650	0	4	_aTransfection
650	0	4	_aTransferases _xantagonists & inhibitors
650	0	4	_aTumor Cells, Cultured
650	0	4	_aValine _xanalogs & derivatives
700	1		_aKline, T
700	1		_aVite, G D
700	1		_aCho, Y H
700	1		_aBhide, R S
700	1		_aPatel, D V
700	1		_aPatel, M M
700	1		_aSchmidt, R J
700	1		_aWeller, H N
700	1		_aAndahazy, M L
700	1		_aCarboni, J M
700	1		_aGullo-Brown, J L
700	1		_aLee, F Y
700	1		_aRicca, C
700	1		_aRose, W C
700	1		_aYan, N
700	1		_aBarbacid, M
700	1		_aHunt, J T
700	1		_aMeyers, C A
700	1		_aSeizinger, B R
700	1		_aZahler, R
700	1		_aManne, V
773	0		_tJournal of medicinal chemistry _gvol. 39 _gno. 1 _gp. 224-36
856	4	0	_uhttps://doi.org/10.1021/jm950642a _zAvailable from publisher's website
999			_c8567886 _d8567886