000 01540 a2200445 4500
005 20250513072050.0
264 0 _c19940315
008 199403s 0 0 eng d
022 _a0022-2623
024 7 _a10.1021/jm00029a001
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aStein, P D
245 0 0 _aThe discovery of sulfonamide endothelin antagonists and the development of the orally active ETA antagonist 5-(dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulf onamide.
_h[electronic resource]
260 _bJournal of medicinal chemistry
_cFeb 1994
300 _a329-31 p.
_bdigital
500 _aPublication Type: Journal Article
650 0 4 _aAnimals
650 0 4 _aAntihypertensive Agents
_xchemical synthesis
650 0 4 _aCell Line
650 0 4 _aDansyl Compounds
_xchemical synthesis
650 0 4 _aEndothelin Receptor Antagonists
650 0 4 _aEndothelins
_xmetabolism
650 0 4 _aHypertension
_xdrug therapy
650 0 4 _aMolecular Structure
650 0 4 _aMuscle, Smooth, Vascular
_xdrug effects
650 0 4 _aRabbits
650 0 4 _aRats
650 0 4 _aStructure-Activity Relationship
700 1 _aHunt, J T
700 1 _aFloyd, D M
700 1 _aMoreland, S
700 1 _aDickinson, K E
700 1 _aMitchell, C
700 1 _aLiu, E C
700 1 _aWebb, M L
700 1 _aMurugesan, N
700 1 _aDickey, J
773 0 _tJournal of medicinal chemistry
_gvol. 37
_gno. 3
_gp. 329-31
856 4 0 _uhttps://doi.org/10.1021/jm00029a001
_zAvailable from publisher's website
999 _c8308137
_d8308137