000			01652 a2200457 4500
005			20250513065352.0
264		0	_c19931216
008			199312s 0 0 eng d
022			_a0818-9641
024	7		_a10.1038/icb.1993.28 _2doi
040			_aNLM _beng _cNLM
100	1		_aXiang, J
245	0	0	_aDifferences in antigen-binding affinity caused by a single amino acid substitution in the variable region of the heavy chain. _h[electronic resource]
260			_bImmunology and cell biology _cAug 1993
300			_a239-47 p. _bdigital
500			_aPublication Type: Journal Article; Research Support, Non-U.S. Gov't
650	0	4	_aAmino Acid Sequence
650	0	4	_aAntibody Affinity
650	0	4	_aAntigens, Neoplasm _ximmunology
650	0	4	_aBase Sequence
650	0	4	_aBinding Sites, Antibody
650	0	4	_aBlotting, Western
650	0	4	_aElectrophoresis, Polyacrylamide Gel
650	0	4	_aEnzyme-Linked Immunosorbent Assay
650	0	4	_aGene Expression
650	0	4	_aHistidine _xgenetics
650	0	4	_aHumans
650	0	4	_aHybridomas _ximmunology
650	0	4	_aImmunoglobulin Heavy Chains _xgenetics
650	0	4	_aImmunoglobulin Variable Region _xgenetics
650	0	4	_aMolecular Sequence Data
650	0	4	_aMutagenesis, Site-Directed
650	0	4	_aRecombinant Fusion Proteins _xmetabolism
650	0	4	_aStructure-Activity Relationship
650	0	4	_aTumor Cells, Cultured
700	1		_aChen, Z
700	1		_aDelbaere, L T
700	1		_aLiu, E
773	0		_tImmunology and cell biology _gvol. 71 ( Pt 4) _gp. 239-47
856	4	0	_uhttps://doi.org/10.1038/icb.1993.28 _zAvailable from publisher's website
999			_c8224677 _d8224677