| 000 | 01756 a2200445 4500 | ||
|---|---|---|---|
| 005 | 20250513035050.0 | ||
| 264 | 0 | _c19950919 | |
| 008 | 199509s 0 0 eng d | ||
| 022 | _a0006-2952 | ||
| 024 | 7 |
_a10.1016/0006-2952(95)00135-m _2doi |
|
| 040 |
_aNLM _beng _cNLM |
||
| 100 | 1 | _aLu, K | |
| 245 | 0 | 0 |
_aMechanisms of resistance to N-[5-[N-(3,4-dihydro-2-methyl-4- oxoquinazolin-6-ylmethyl)-N-methylamino]-2-thenoyl]-L-glutamic acid (ZD1694), a folate-based thymidylate synthase inhibitor, in the HCT-8 human ileocecal adenocarcinoma cell line. _h[electronic resource] |
| 260 |
_bBiochemical pharmacology _cJul 1995 |
||
| 300 |
_a391-8 p. _bdigital |
||
| 500 | _aPublication Type: Journal Article; Research Support, U.S. Gov't, P.H.S. | ||
| 650 | 0 | 4 |
_aCell Division _xdrug effects |
| 650 | 0 | 4 | _aCell-Free System |
| 650 | 0 | 4 | _aDose-Response Relationship, Drug |
| 650 | 0 | 4 | _aDrug Resistance |
| 650 | 0 | 4 |
_aFolic Acid Antagonists _xpharmacology |
| 650 | 0 | 4 |
_aGlutamates _xpharmacology |
| 650 | 0 | 4 |
_aGuanine _xanalogs & derivatives |
| 650 | 0 | 4 | _aHumans |
| 650 | 0 | 4 |
_aMethotrexate _xpharmacology |
| 650 | 0 | 4 | _aPemetrexed |
| 650 | 0 | 4 |
_aPeptide Synthases _xantagonists & inhibitors |
| 650 | 0 | 4 |
_aPteroylpolyglutamic Acids _xmetabolism |
| 650 | 0 | 4 |
_aQuinazolines _xpharmacology |
| 650 | 0 | 4 |
_aThiophenes _xpharmacology |
| 650 | 0 | 4 |
_aThymidylate Synthase _xantagonists & inhibitors |
| 650 | 0 | 4 | _aTime Factors |
| 650 | 0 | 4 |
_aTumor Cells, Cultured _xdrug effects |
| 700 | 1 | _aYin, M B | |
| 700 | 1 | _aMcGuire, J J | |
| 700 | 1 | _aBonmassar, E | |
| 700 | 1 | _aRustum, Y M | |
| 773 | 0 |
_tBiochemical pharmacology _gvol. 50 _gno. 3 _gp. 391-8 |
|
| 856 | 4 | 0 |
_uhttps://doi.org/10.1016/0006-2952(95)00135-m _zAvailable from publisher's website |
| 999 |
_c7645972 _d7645972 |
||