000 01888 a2200505 4500
005 20250513031146.0
264 0 _c19941117
008 199411s 0 0 eng d
022 _a0021-9258
040 _aNLM
_beng
_cNLM
100 1 _aJonckheere, H
245 0 0 _aResistance of HIV-1 reverse transcriptase against [2',5'-bis-O-(tert-butyldimethylsilyl)-3'-spiro-5''-(4''-amino-1'',2''- oxathiole-2'',2''-dioxide)] (TSAO) derivatives is determined by the mutation Glu138-->Lys on the p51 subunit.
_h[electronic resource]
260 _bThe Journal of biological chemistry
_cOct 1994
300 _a25255-8 p.
_bdigital
500 _aPublication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
650 0 4 _aAntiviral Agents
_xchemistry
650 0 4 _aBase Sequence
650 0 4 _aBenzodiazepines
_xpharmacology
650 0 4 _aBinding Sites
_xgenetics
650 0 4 _aDeoxyguanine Nucleotides
_xpharmacology
650 0 4 _aDideoxynucleotides
650 0 4 _aDrug Resistance
_xgenetics
650 0 4 _aEscherichia coli
_xgenetics
650 0 4 _aHIV Reverse Transcriptase
650 0 4 _aImidazoles
_xpharmacology
650 0 4 _aMolecular Sequence Data
650 0 4 _aMutagenesis, Site-Directed
650 0 4 _aMutation
650 0 4 _aProtein Conformation
650 0 4 _aRNA-Directed DNA Polymerase
_xgenetics
650 0 4 _aRecombinant Proteins
_xmetabolism
650 0 4 _aReverse Transcriptase Inhibitors
650 0 4 _aSequence Analysis, DNA
650 0 4 _aSpiro Compounds
650 0 4 _aThymidine
_xanalogs & derivatives
650 0 4 _aUridine
_xanalogs & derivatives
700 1 _aTaymans, J M
700 1 _aBalzarini, J
700 1 _aVelázquez, S
700 1 _aCamarasa, M J
700 1 _aDesmyter, J
700 1 _aDe Clercq, E
700 1 _aAnné, J
773 0 _tThe Journal of biological chemistry
_gvol. 269
_gno. 41
_gp. 25255-8
999 _c7522850
_d7522850