000 01895 a2200493 4500
005 20250518095949.0
264 0 _c20210614
008 202106s 0 0 eng d
022 _a1860-7187
024 7 _a10.1002/cmdc.202000160
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aBehnisch-Cornwell, Steven
245 0 0 _aPentathiepins: A Novel Class of Glutathione Peroxidase 1 Inhibitors that Induce Oxidative Stress, Loss of Mitochondrial Membrane Potential and Apoptosis in Human Cancer Cells.
_h[electronic resource]
260 _bChemMedChem
_c08 2020
300 _a1515-1528 p.
_bdigital
500 _aPublication Type: Journal Article
650 0 4 _aAntineoplastic Agents
_xchemical synthesis
650 0 4 _aApoptosis
_xdrug effects
650 0 4 _aCell Proliferation
_xdrug effects
650 0 4 _aCell Survival
_xdrug effects
650 0 4 _aDose-Response Relationship, Drug
650 0 4 _aDrug Screening Assays, Antitumor
650 0 4 _aEnzyme Inhibitors
_xchemical synthesis
650 0 4 _aGlutathione Peroxidase
_xantagonists & inhibitors
650 0 4 _aHeterocyclic Compounds
_xchemical synthesis
650 0 4 _aHumans
650 0 4 _aMembrane Potential, Mitochondrial
_xdrug effects
650 0 4 _aMolecular Structure
650 0 4 _aOxidative Stress
_xdrug effects
650 0 4 _aStructure-Activity Relationship
650 0 4 _aSulfides
_xchemical synthesis
650 0 4 _aTumor Cells, Cultured
650 0 4 _aGlutathione Peroxidase GPX1
700 1 _aBandaru, Siva Sankar Murthy
700 1 _aNapierkowski, Martin
700 1 _aWolff, Lisa
700 1 _aZubair, Muhammad
700 1 _aUrbainsky, Claudia
700 1 _aLillig, Christopher
700 1 _aSchulzke, Carola
700 1 _aBednarski, Patrick J
773 0 _tChemMedChem
_gvol. 15
_gno. 16
_gp. 1515-1528
856 4 0 _uhttps://doi.org/10.1002/cmdc.202000160
_zAvailable from publisher's website
999 _c30877715
_d30877715