000 02089 a2200577 4500
005 20250518095611.0
264 0 _c20201201
008 202012s 0 0 eng d
022 _a1873-2968
024 7 _a10.1016/j.bcp.2020.113977
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aSbardella, Diego
245 0 0 _aStructural and functional evidence for citicoline binding and modulation of 20S proteasome activity: Novel insights into its pro-proteostatic effect.
_h[electronic resource]
260 _bBiochemical pharmacology
_c07 2020
300 _a113977 p.
_bdigital
500 _aPublication Type: Journal Article; Research Support, Non-U.S. Gov't
650 0 4 _aAllosteric Regulation
650 0 4 _aAmino Acid Sequence
650 0 4 _aBinding Sites
650 0 4 _aCell Line, Tumor
650 0 4 _aCytidine Diphosphate Choline
_xchemistry
650 0 4 _aGene Expression
650 0 4 _aHumans
650 0 4 _aKinetics
650 0 4 _aMolecular Docking Simulation
650 0 4 _aNeurons
_xdrug effects
650 0 4 _aNeuroprotective Agents
_xchemistry
650 0 4 _aNootropic Agents
_xchemistry
650 0 4 _aProteasome Endopeptidase Complex
_xchemistry
650 0 4 _aProteasome Inhibitors
_xchemistry
650 0 4 _aProtein Binding
650 0 4 _aProtein Conformation, alpha-Helical
650 0 4 _aProtein Conformation, beta-Strand
650 0 4 _aProtein Interaction Domains and Motifs
650 0 4 _aProteostasis
_xdrug effects
650 0 4 _aRecombinant Proteins
_xchemistry
650 0 4 _aSequence Alignment
650 0 4 _aSequence Homology, Amino Acid
650 0 4 _aSubstrate Specificity
650 0 4 _aThermodynamics
650 0 4 _aalpha-Synuclein
_xchemistry
700 1 _aColetta, Andrea
700 1 _aTundo, Grazia Raffaella
700 1 _aAhmed, Ikhlas M M
700 1 _aBellia, Francesco
700 1 _aOddone, Francesco
700 1 _aManni, Gianluca
700 1 _aColetta, Massimo
773 0 _tBiochemical pharmacology
_gvol. 177
_gp. 113977
856 4 0 _uhttps://doi.org/10.1016/j.bcp.2020.113977
_zAvailable from publisher's website
999 _c30865583
_d30865583