000 01607 a2200505 4500
005 20250518095143.0
264 0 _c20201007
008 202010s 0 0 eng d
022 _a1546-1696
024 7 _a10.1038/s41587-020-0491-6
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aGaudelli, Nicole M
245 0 0 _aDirected evolution of adenine base editors with increased activity and therapeutic application.
_h[electronic resource]
260 _bNature biotechnology
_c07 2020
300 _a892-900 p.
_bdigital
500 _aPublication Type: Journal Article
650 0 4 _aAdenine
_xmetabolism
650 0 4 _aAdenosine Deaminase
650 0 4 _aCRISPR-Cas Systems
_xgenetics
650 0 4 _aCytosine
_xmetabolism
650 0 4 _aDNA
_xgenetics
650 0 4 _aGene Editing
_xmethods
650 0 4 _aHEK293 Cells
650 0 4 _aHumans
650 0 4 _aMutation
_xgenetics
650 0 4 _aRNA, Guide, CRISPR-Cas Systems
700 1 _aLam, Dieter K
700 1 _aRees, Holly A
700 1 _aSolá-Esteves, Noris M
700 1 _aBarrera, Luis A
700 1 _aBorn, David A
700 1 _aEdwards, Aaron
700 1 _aGehrke, Jason M
700 1 _aLee, Seung-Joo
700 1 _aLiquori, Alexander J
700 1 _aMurray, Ryan
700 1 _aPacker, Michael S
700 1 _aRinaldi, Conrad
700 1 _aSlaymaker, Ian M
700 1 _aYen, Jonathan
700 1 _aYoung, Lauren E
700 1 _aCiaramella, Giuseppe
773 0 _tNature biotechnology
_gvol. 38
_gno. 7
_gp. 892-900
856 4 0 _uhttps://doi.org/10.1038/s41587-020-0491-6
_zAvailable from publisher's website
999 _c30851732
_d30851732