000			01673 a2200445 4500
005			20250518094952.0
264		0	_c20210302
008			202103s 0 0 eng d
022			_a1090-2120
024	7		_a10.1016/j.bioorg.2020.103814 _2doi
040			_aNLM _beng _cNLM
100	1		_aHuang, Wan-Yun
245	0	0	_aPyridazino[1,6-b]quinazolinones as new anticancer scaffold: Synthesis, DNA intercalation, topoisomerase I inhibition and antitumor evaluation in vitro and in vivo. _h[electronic resource]
260			_bBioorganic chemistry _c06 2020
300			_a103814 p. _bdigital
500			_aPublication Type: Journal Article; Research Support, Non-U.S. Gov't
650	0	4	_aAnimals
650	0	4	_aAntineoplastic Agents _xchemical synthesis
650	0	4	_aApoptosis _xdrug effects
650	0	4	_aCattle
650	0	4	_aCell Cycle _xdrug effects
650	0	4	_aCell Proliferation _xdrug effects
650	0	4	_aDNA _xchemistry
650	0	4	_aDNA Topoisomerases, Type I _xmetabolism
650	0	4	_aDose-Response Relationship, Drug
650	0	4	_aDrug Screening Assays, Antitumor
650	0	4	_aHumans
650	0	4	_aMolecular Docking Simulation
650	0	4	_aMolecular Structure
650	0	4	_aQuinazolinones _xchemical synthesis
650	0	4	_aStructure-Activity Relationship
650	0	4	_aTopoisomerase I Inhibitors _xchemical synthesis
650	0	4	_aTumor Cells, Cultured
700	1		_aZhang, Xiao-Rong
700	1		_aLyu, Liang
700	1		_aWang, Shu-Qin
700	1		_aZhang, Xiao-Ting
773	0		_tBioorganic chemistry _gvol. 99 _gp. 103814
856	4	0	_uhttps://doi.org/10.1016/j.bioorg.2020.103814 _zAvailable from publisher's website
999			_c30845435 _d30845435