000 01732 a2200469 4500
005 20250518094824.0
264 0 _c20210430
008 202104s 0 0 eng d
022 _a1464-3405
024 7 _a10.1016/j.bmcl.2020.127170
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aSatheeshkumar, Rajendran
245 0 0 _aSynthesis and biological evaluation of heterocyclic bis-aryl amides as novel Src homology 2 domain containing protein tyrosine phosphatase-2 (SHP2) inhibitors.
_h[electronic resource]
260 _bBioorganic & medicinal chemistry letters
_c06 2020
300 _a127170 p.
_bdigital
500 _aPublication Type: Journal Article; Research Support, Non-U.S. Gov't
650 0 4 _aAmides
_xchemistry
650 0 4 _aBinding Sites
650 0 4 _aEnzyme Inhibitors
_xchemical synthesis
650 0 4 _aHeterocyclic Compounds
_xchemistry
650 0 4 _aHumans
650 0 4 _aKinetics
650 0 4 _aMolecular Docking Simulation
650 0 4 _aProtein Tyrosine Phosphatase, Non-Receptor Type 1
_xantagonists & inhibitors
650 0 4 _aProtein Tyrosine Phosphatase, Non-Receptor Type 11
_xantagonists & inhibitors
650 0 4 _aStructure-Activity Relationship
650 0 4 _asrc Homology Domains
700 1 _aZhu, Rui
700 1 _aFeng, Bo
700 1 _aHuang, Chao
700 1 _aGao, Ya
700 1 _aGao, Li-Xin
700 1 _aShen, Chao
700 1 _aHou, Ting-Jun
700 1 _aXu, Lei
700 1 _aLi, Jia
700 1 _aZhu, Yun-Long
700 1 _aZhou, Yu-Bo
700 1 _aWang, Wen-Long
773 0 _tBioorganic & medicinal chemistry letters
_gvol. 30
_gno. 11
_gp. 127170
856 4 0 _uhttps://doi.org/10.1016/j.bmcl.2020.127170
_zAvailable from publisher's website
999 _c30840496
_d30840496