000 02937 a2200865 4500
005 20250518094218.0
264 0 _c20200504
008 202005s 0 0 eng d
022 _a1946-6242
024 7 _a10.1126/scitranslmed.abb5883
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aSheahan, Timothy P
245 0 0 _aAn orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice.
_h[electronic resource]
260 _bScience translational medicine
_c04 2020
500 _aPublication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
650 0 4 _aAdenosine Monophosphate
_xadministration & dosage
650 0 4 _aAlanine
_xadministration & dosage
650 0 4 _aAnimals
650 0 4 _aAntibiotic Prophylaxis
650 0 4 _aAntiviral Agents
_xadministration & dosage
650 0 4 _aBetacoronavirus
_xphysiology
650 0 4 _aCOVID-19
650 0 4 _aCell Line
650 0 4 _aCoronavirus Infections
_xdrug therapy
650 0 4 _aCytidine
_xadministration & dosage
650 0 4 _aDisease Models, Animal
650 0 4 _aDrug Resistance, Viral
650 0 4 _aHumans
650 0 4 _aHydroxylamines
650 0 4 _aLung
_xpathology
650 0 4 _aMice
650 0 4 _aMice, Inbred C57BL
650 0 4 _aMiddle East Respiratory Syndrome Coronavirus
_xphysiology
650 0 4 _aModels, Molecular
650 0 4 _aMutation
_xdrug effects
650 0 4 _aPandemics
650 0 4 _aPneumonia, Viral
_xdrug therapy
650 0 4 _aPrimary Cell Culture
650 0 4 _aRNA, Viral
650 0 4 _aRNA-Dependent RNA Polymerase
_xchemistry
650 0 4 _aRandom Allocation
650 0 4 _aRespiratory System
_xcytology
650 0 4 _aRibonucleosides
_xadministration & dosage
650 0 4 _aSARS-CoV-2
650 0 4 _aVirus Replication
_xdrug effects
700 1 _aSims, Amy C
700 1 _aZhou, Shuntai
700 1 _aGraham, Rachel L
700 1 _aPruijssers, Andrea J
700 1 _aAgostini, Maria L
700 1 _aLeist, Sarah R
700 1 _aSchäfer, Alexandra
700 1 _aDinnon, Kenneth H
700 1 _aStevens, Laura J
700 1 _aChappell, James D
700 1 _aLu, Xiaotao
700 1 _aHughes, Tia M
700 1 _aGeorge, Amelia S
700 1 _aHill, Collin S
700 1 _aMontgomery, Stephanie A
700 1 _aBrown, Ariane J
700 1 _aBluemling, Gregory R
700 1 _aNatchus, Michael G
700 1 _aSaindane, Manohar
700 1 _aKolykhalov, Alexander A
700 1 _aPainter, George
700 1 _aHarcourt, Jennifer
700 1 _aTamin, Azaibi
700 1 _aThornburg, Natalie J
700 1 _aSwanstrom, Ronald
700 1 _aDenison, Mark R
700 1 _aBaric, Ralph S
773 0 _tScience translational medicine
_gvol. 12
_gno. 541
856 4 0 _uhttps://doi.org/10.1126/scitranslmed.abb5883
_zAvailable from publisher's website
999 _c30820717
_d30820717