000			02130 a2200625 4500
005			20250518093601.0
264		0	_c20200824
008			202008s 0 0 eng d
022			_a1546-170X
024	7		_a10.1038/s41591-020-0806-7 _2doi
040			_aNLM _beng _cNLM
100	1		_aKrystal, Andrew D
245	0	0	_aA randomized proof-of-mechanism trial applying the 'fast-fail' approach to evaluating κ-opioid antagonism as a treatment for anhedonia. _h[electronic resource]
260			_bNature medicine _c05 2020
300			_a760-768 p. _bdigital
500			_aPublication Type: Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural
650	0	4	_aAdult
650	0	4	_aAnhedonia _xdrug effects
650	0	4	_aAnxiety Disorders _xcomplications
650	0	4	_aBenzamides _xtherapeutic use
650	0	4	_aCentral Nervous System Agents _xtherapeutic use
650	0	4	_aDouble-Blind Method
650	0	4	_aFemale
650	0	4	_aHumans
650	0	4	_aMale
650	0	4	_aMiddle Aged
650	0	4	_aMood Disorders _xcomplications
650	0	4	_aNarcotic Antagonists _xtherapeutic use
650	0	4	_aProof of Concept Study
650	0	4	_aPyrrolidines _xtherapeutic use
650	0	4	_aReceptors, Opioid, kappa _xantagonists & inhibitors
650	0	4	_aTime Factors
650	0	4	_aTreatment Outcome
700	1		_aPizzagalli, Diego A
700	1		_aSmoski, Moria
700	1		_aMathew, Sanjay J
700	1		_aNurnberger, John
700	1		_aLisanby, Sarah H
700	1		_aIosifescu, Dan
700	1		_aMurrough, James W
700	1		_aYang, Hongqiu
700	1		_aWeiner, Richard D
700	1		_aCalabrese, Joseph R
700	1		_aSanacora, Gerard
700	1		_aHermes, Gretchen
700	1		_aKeefe, Richard S E
700	1		_aSong, Allen
700	1		_aGoodman, Wayne
700	1		_aSzabo, Steven T
700	1		_aWhitton, Alexis E
700	1		_aGao, Keming
700	1		_aPotter, William Z
773	0		_tNature medicine _gvol. 26 _gno. 5 _gp. 760-768
856	4	0	_uhttps://doi.org/10.1038/s41591-020-0806-7 _zAvailable from publisher's website
999			_c30799075 _d30799075