000			02123 a2200637 4500
005			20250518092748.0
264		0	_c20200626
008			202006s 0 0 eng d
022			_a1546-1718
024	7		_a10.1038/s41588-020-0590-9 _2doi
040			_aNLM _beng _cNLM
100	1		_aLin, Kevin H
245	0	0	_aUsing antagonistic pleiotropy to design a chemotherapy-induced evolutionary trap to target drug resistance in cancer. _h[electronic resource]
260			_bNature genetics _c04 2020
300			_a408-417 p. _bdigital
500			_aPublication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
650	0	4	_aAdaptation, Physiological _xgenetics
650	0	4	_aAnimals
650	0	4	_aBiological Evolution
650	0	4	_aCRISPR-Cas Systems _xgenetics
650	0	4	_aCell Line
650	0	4	_aCell Line, Tumor
650	0	4	_aDrug Resistance, Neoplasm _xgenetics
650	0	4	_aEnvironment
650	0	4	_aGenetic Fitness _xgenetics
650	0	4	_aGenetic Pleiotropy _xgenetics
650	0	4	_aHEK293 Cells
650	0	4	_aHL-60 Cells
650	0	4	_aHumans
650	0	4	_aMice
650	0	4	_aNeoplasms _xgenetics
650	0	4	_aNuclear Proteins _xgenetics
650	0	4	_aPhenotype
650	0	4	_aQuantitative Trait Loci _xgenetics
650	0	4	_aTranscription Factors _xgenetics
700	1		_aRutter, Justine C
700	1		_aXie, Abigail
700	1		_aPardieu, Bryann
700	1		_aWinn, Emily T
700	1		_aBello, Reinaldo Dal
700	1		_aForget, Antoine
700	1		_aItzykson, Raphael
700	1		_aAhn, Yeong-Ran
700	1		_aDai, Ziwei
700	1		_aSobhan, Raiyan T
700	1		_aAnderson, Gray R
700	1		_aSingleton, Katherine R
700	1		_aDecker, Amy E
700	1		_aWinter, Peter S
700	1		_aLocasale, Jason W
700	1		_aCrawford, Lorin
700	1		_aPuissant, Alexandre
700	1		_aWood, Kris C
773	0		_tNature genetics _gvol. 52 _gno. 4 _gp. 408-417
856	4	0	_uhttps://doi.org/10.1038/s41588-020-0590-9 _zAvailable from publisher's website
999			_c30771906 _d30771906