000 01641 a2200445 4500
005 20250518092654.0
264 0 _c20210224
008 202102s 0 0 eng d
022 _a1090-2120
024 7 _a10.1016/j.bioorg.2020.103755
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aÁlvarez, Raquel
245 0 0 _aPotent colchicine-site ligands with improved intrinsic solubility by replacement of the 3,4,5-trimethoxyphenyl ring with a 2-methylsulfanyl-6-methoxypyridine ring.
_h[electronic resource]
260 _bBioorganic chemistry
_c05 2020
300 _a103755 p.
_bdigital
500 _aPublication Type: Journal Article; Research Support, Non-U.S. Gov't
650 0 4 _aAntineoplastic Agents
_xchemical synthesis
650 0 4 _aCell Cycle
_xdrug effects
650 0 4 _aCell Proliferation
_xdrug effects
650 0 4 _aColchicine
_xchemical synthesis
650 0 4 _aDose-Response Relationship, Drug
650 0 4 _aDrug Screening Assays, Antitumor
650 0 4 _aHumans
650 0 4 _aLigands
650 0 4 _aMolecular Structure
650 0 4 _aPolymerization
_xdrug effects
650 0 4 _aPyridines
_xchemistry
650 0 4 _aSolubility
650 0 4 _aStructure-Activity Relationship
650 0 4 _aTubulin
_xmetabolism
650 0 4 _aTumor Cells, Cultured
700 1 _aAramburu, Laura
700 1 _aGajate, Consuelo
700 1 _aVicente-Blázquez, Alba
700 1 _aMollinedo, Faustino
700 1 _aMedarde, Manuel
700 1 _aPeláez, Rafael
773 0 _tBioorganic chemistry
_gvol. 98
_gp. 103755
856 4 0 _uhttps://doi.org/10.1016/j.bioorg.2020.103755
_zAvailable from publisher's website
999 _c30768858
_d30768858