000 02114 a2200637 4500
005 20250518090130.0
264 0 _c20200914
008 202009s 0 0 eng d
022 _a1520-4804
024 7 _a10.1021/acs.jmedchem.9b02123
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aLiddle, John
245 0 0 _aTargeting the Regulatory Site of ER Aminopeptidase 1 Leads to the Discovery of a Natural Product Modulator of Antigen Presentation.
_h[electronic resource]
260 _bJournal of medicinal chemistry
_c03 2020
300 _a3348-3358 p.
_bdigital
500 _aPublication Type: Journal Article
650 0 4 _aAllosteric Site
650 0 4 _aAminopeptidases
_xantagonists & inhibitors
650 0 4 _aAnimals
650 0 4 _aAntigen Presentation
_xdrug effects
650 0 4 _aCatalytic Domain
650 0 4 _aCrystallography, X-Ray
650 0 4 _aDiterpenes, Clerodane
_xchemistry
650 0 4 _aEnzyme Activators
_xchemistry
650 0 4 _aEpitopes
_xchemistry
650 0 4 _aHeLa Cells
650 0 4 _aHumans
650 0 4 _aMice
650 0 4 _aMinor Histocompatibility Antigens
_xchemistry
650 0 4 _aPeptides
_xchemistry
650 0 4 _aProtease Inhibitors
_xchemistry
650 0 4 _aProtein Binding
650 0 4 _aProteolysis
_xdrug effects
700 1 _aHutchinson, Jonathan P
700 1 _aKitchen, Semra
700 1 _aRowland, Paul
700 1 _aNeu, Margarete
700 1 _aCecconie, Ted
700 1 _aHolmes, Duncan S
700 1 _aJones, Emma
700 1 _aKorczynska, Justyna
700 1 _aKoumantou, Despoina
700 1 _aLea, Jonathan D
700 1 _aNickels, Leng
700 1 _aPemberton, Michelle
700 1 _aPhillipou, Alex
700 1 _aSchneck, Jessica L
700 1 _aSheehan, Hester
700 1 _aTinworth, Christopher P
700 1 _aUings, Iain
700 1 _aWojno-Picon, Justyna
700 1 _aYoung, Robert J
700 1 _aStratikos, Efstratios
773 0 _tJournal of medicinal chemistry
_gvol. 63
_gno. 6
_gp. 3348-3358
856 4 0 _uhttps://doi.org/10.1021/acs.jmedchem.9b02123
_zAvailable from publisher's website
999 _c30683521
_d30683521