000 01359 a2200409 4500
005 20250518085219.0
264 0 _c20201021
008 202010s 0 0 eng d
022 _a2375-2548
024 7 _a10.1126/sciadv.aay0187
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aAschenbrenner, Sabine
245 0 0 _aCoupling Cas9 to artificial inhibitory domains enhances CRISPR-Cas9 target specificity.
_h[electronic resource]
260 _bScience advances
_c02 2020
300 _aeaay0187 p.
_bdigital
500 _aPublication Type: Journal Article; Research Support, Non-U.S. Gov't
650 0 4 _aCRISPR-Associated Protein 9
_xchemistry
650 0 4 _aCRISPR-Cas Systems
650 0 4 _aCell Line
650 0 4 _aEnzyme Activation
650 0 4 _aGene Editing
650 0 4 _aGene Targeting
_xmethods
650 0 4 _aGenes, Reporter
650 0 4 _aGenetic Loci
650 0 4 _aHumans
650 0 4 _aKinetics
650 0 4 _aModels, Theoretical
650 0 4 _aRecombinant Fusion Proteins
650 0 4 _aSubstrate Specificity
700 1 _aKallenberger, Stefan M
700 1 _aHoffmann, Mareike D
700 1 _aHuck, Adrian
700 1 _aEils, Roland
700 1 _aNiopek, Dominik
773 0 _tScience advances
_gvol. 6
_gno. 6
_gp. eaay0187
856 4 0 _uhttps://doi.org/10.1126/sciadv.aay0187
_zAvailable from publisher's website
999 _c30652783
_d30652783