000 02260 a2200649 4500
005 20250518074400.0
264 0 _c20200817
008 202008s 0 0 eng d
022 _a1755-4349
024 7 _a10.1038/s41557-019-0378-7
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aLe, Philipp
245 0 0 _aRepurposing human kinase inhibitors to create an antibiotic active against drug-resistant Staphylococcus aureus, persisters and biofilms.
_h[electronic resource]
260 _bNature chemistry
_c02 2020
300 _a145-158 p.
_bdigital
500 _aPublication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
650 0 4 _aAnimals
650 0 4 _aAnti-Bacterial Agents
_xchemical synthesis
650 0 4 _aAutolysis
_xchemically induced
650 0 4 _aBenzodioxoles
_xchemical synthesis
650 0 4 _aBiofilms
_xdrug effects
650 0 4 _aCell Line, Tumor
650 0 4 _aDrug Repositioning
650 0 4 _aFemale
650 0 4 _aHumans
650 0 4 _aMale
650 0 4 _aMethicillin-Resistant Staphylococcus aureus
_xdrug effects
650 0 4 _aMice, Inbred C57BL
650 0 4 _aMicrobial Sensitivity Tests
650 0 4 _aMolecular Dynamics Simulation
650 0 4 _aMolecular Structure
650 0 4 _aProtein Kinase Inhibitors
_xchemistry
650 0 4 _aSorafenib
_xanalogs & derivatives
650 0 4 _aStructure-Activity Relationship
700 1 _aKunold, Elena
700 1 _aMacsics, Robert
700 1 _aRox, Katharina
700 1 _aJennings, Megan C
700 1 _aUgur, Ilke
700 1 _aReinecke, Maria
700 1 _aChaves-Moreno, Diego
700 1 _aHackl, Mathias W
700 1 _aFetzer, Christian
700 1 _aMandl, Franziska A M
700 1 _aLehmann, Johannes
700 1 _aKorotkov, Vadim S
700 1 _aHacker, Stephan M
700 1 _aKuster, Bernhard
700 1 _aAntes, Iris
700 1 _aPieper, Dietmar H
700 1 _aRohde, Manfred
700 1 _aWuest, William M
700 1 _aMedina, Eva
700 1 _aSieber, Stephan A
773 0 _tNature chemistry
_gvol. 12
_gno. 2
_gp. 145-158
856 4 0 _uhttps://doi.org/10.1038/s41557-019-0378-7
_zAvailable from publisher's website
999 _c30427586
_d30427586