000 02103 a2200601 4500
005 20250518071456.0
264 0 _c20200619
008 202006s 0 0 eng d
022 _a1538-7445
024 7 _a10.1158/0008-5472.CAN-19-0650
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aKaymak, Irem
245 0 0 _aMevalonate Pathway Provides Ubiquinone to Maintain Pyrimidine Synthesis and Survival in p53-Deficient Cancer Cells Exposed to Metabolic Stress.
_h[electronic resource]
260 _bCancer research
_c01 2020
300 _a189-203 p.
_bdigital
500 _aPublication Type: Journal Article; Research Support, Non-U.S. Gov't
650 0 4 _aAnimals
650 0 4 _aApoptosis
650 0 4 _aCell Line, Tumor
650 0 4 _aCell Survival
650 0 4 _aCitric Acid Cycle
_xdrug effects
650 0 4 _aHumans
650 0 4 _aHydroxymethylglutaryl-CoA Reductase Inhibitors
_xpharmacology
650 0 4 _aIntestinal Mucosa
_xcytology
650 0 4 _aMevalonic Acid
_xmetabolism
650 0 4 _aMice
650 0 4 _aMice, Transgenic
650 0 4 _aNeoplasms
_xgenetics
650 0 4 _aPyrimidines
_xmetabolism
650 0 4 _aSignal Transduction
_xdrug effects
650 0 4 _aSterol Regulatory Element Binding Protein 2
_xmetabolism
650 0 4 _aStress, Physiological
650 0 4 _aTumor Microenvironment
_xgenetics
650 0 4 _aTumor Suppressor Protein p53
_xgenetics
650 0 4 _aUbiquinone
_xanalogs & derivatives
650 0 4 _aXenograft Model Antitumor Assays
700 1 _aMaier, Carina R
700 1 _aSchmitz, Werner
700 1 _aCampbell, Andrew D
700 1 _aDankworth, Beatrice
700 1 _aAde, Carsten P
700 1 _aWalz, Susanne
700 1 _aPaauwe, Madelon
700 1 _aKalogirou, Charis
700 1 _aMarouf, Hecham
700 1 _aRosenfeldt, Mathias T
700 1 _aGay, David M
700 1 _aMcGregor, Grace H
700 1 _aSansom, Owen J
700 1 _aSchulze, Almut
773 0 _tCancer research
_gvol. 80
_gno. 2
_gp. 189-203
856 4 0 _uhttps://doi.org/10.1158/0008-5472.CAN-19-0650
_zAvailable from publisher's website
999 _c30330251
_d30330251