000 01902 a2200493 4500
005 20250518065455.0
264 0 _c20201016
008 202010s 0 0 eng d
022 _a1873-4847
024 7 _a10.1016/j.jnutbio.2019.108227
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aWu, Chi-Shiuan
245 0 0 _aCurcumin functions as a MEK inhibitor to induce a synthetic lethal effect on KRAS mutant colorectal cancer cells receiving targeted drug regorafenib.
_h[electronic resource]
260 _bThe Journal of nutritional biochemistry
_c12 2019
300 _a108227 p.
_bdigital
500 _aPublication Type: Journal Article; Research Support, Non-U.S. Gov't
650 0 4 _aAntineoplastic Combined Chemotherapy Protocols
_xpharmacology
650 0 4 _aApoptosis
_xdrug effects
650 0 4 _aButadienes
_xpharmacology
650 0 4 _aColorectal Neoplasms
_xdrug therapy
650 0 4 _aCurcumin
_xadministration & dosage
650 0 4 _aGene Expression Regulation, Neoplastic
_xdrug effects
650 0 4 _aHCT116 Cells
650 0 4 _aHT29 Cells
650 0 4 _aHumans
650 0 4 _aMAP Kinase Kinase Kinases
_xantagonists & inhibitors
650 0 4 _aMutation
650 0 4 _aNitriles
_xpharmacology
650 0 4 _aPhenylurea Compounds
_xadministration & dosage
650 0 4 _aProtein Kinase Inhibitors
_xpharmacology
650 0 4 _aProto-Oncogene Proteins p21(ras)
_xgenetics
650 0 4 _aPyridines
_xadministration & dosage
700 1 _aWu, Shan-Ying
700 1 _aChen, Hsin-Chih
700 1 _aChu, Chien-An
700 1 _aTang, Han-Hsuan
700 1 _aLiu, Hsiao-Sheng
700 1 _aHong, Yi-Ren
700 1 _aHuang, Chi-Ying F
700 1 _aHuang, Guan-Cheng
700 1 _aSu, Chun-Li
773 0 _tThe Journal of nutritional biochemistry
_gvol. 74
_gp. 108227
856 4 0 _uhttps://doi.org/10.1016/j.jnutbio.2019.108227
_zAvailable from publisher's website
999 _c30262438
_d30262438