000 02090 a2200613 4500
005 20250518064201.0
264 0 _c20200114
008 202001s 0 0 eng d
022 _a2041-1723
024 7 _a10.1038/s41467-019-12657-w
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aMichaelis, Katherine A
245 0 0 _aThe TLR7/8 agonist R848 remodels tumor and host responses to promote survival in pancreatic cancer.
_h[electronic resource]
260 _bNature communications
_c10 2019
300 _a4682 p.
_bdigital
500 _aPublication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
650 0 4 _aAnimals
650 0 4 _aBody Weight
_xdrug effects
650 0 4 _aCD8-Positive T-Lymphocytes
_ximmunology
650 0 4 _aCachexia
650 0 4 _aCarcinoma, Pancreatic Ductal
_xgenetics
650 0 4 _aCell Line, Tumor
650 0 4 _aEating
_xdrug effects
650 0 4 _aGene Expression
650 0 4 _aHumans
650 0 4 _aImidazoles
_xpharmacology
650 0 4 _aLocomotion
_xdrug effects
650 0 4 _aMice
650 0 4 _aMice, Knockout
650 0 4 _aPancreatic Intraductal Neoplasms
_xgenetics
650 0 4 _aPancreatic Neoplasms
_xgenetics
650 0 4 _aSequence Analysis, RNA
650 0 4 _aSurvival Rate
650 0 4 _aToll-Like Receptor 7
_xagonists
650 0 4 _aToll-Like Receptor 8
_xagonists
650 0 4 _aTumor Burden
650 0 4 _aTumor Microenvironment
_xdrug effects
700 1 _aNorgard, Mason A
700 1 _aZhu, Xinxia
700 1 _aLevasseur, Peter R
700 1 _aSivagnanam, Shamilene
700 1 _aLiudahl, Shannon M
700 1 _aBurfeind, Kevin G
700 1 _aOlson, Brennan
700 1 _aPelz, Katherine R
700 1 _aAngeles Ramos, Diana M
700 1 _aMaurer, H Carlo
700 1 _aOlive, Kenneth P
700 1 _aCoussens, Lisa M
700 1 _aMorgan, Terry K
700 1 _aMarks, Daniel L
773 0 _tNature communications
_gvol. 10
_gno. 1
_gp. 4682
856 4 0 _uhttps://doi.org/10.1038/s41467-019-12657-w
_zAvailable from publisher's website
999 _c30204976
_d30204976