000 01638 a2200433 4500
005 20250518055210.0
264 0 _c20200326
008 202003s 0 0 eng d
022 _a1091-6490
024 7 _a10.1073/pnas.1907869116
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aChure, Griffin
245 0 0 _aPredictive shifts in free energy couple mutations to their phenotypic consequences.
_h[electronic resource]
260 _bProceedings of the National Academy of Sciences of the United States of America
_c09 2019
300 _a18275-18284 p.
_bdigital
500 _aPublication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
650 0 4 _aAlgorithms
650 0 4 _aAllosteric Regulation
650 0 4 _aDNA-Binding Proteins
_xgenetics
650 0 4 _aEnergy Metabolism
_xgenetics
650 0 4 _aEscherichia coli
_xgenetics
650 0 4 _aGene Dosage
650 0 4 _aGenetic Association Studies
650 0 4 _aLac Repressors
_xgenetics
650 0 4 _aModels, Biological
650 0 4 _aMutation
650 0 4 _aOperator Regions, Genetic
650 0 4 _aPhenotype
650 0 4 _aProtein Interaction Domains and Motifs
700 1 _aRazo-Mejia, Manuel
700 1 _aBelliveau, Nathan M
700 1 _aEinav, Tal
700 1 _aKaczmarek, Zofii A
700 1 _aBarnes, Stephanie L
700 1 _aLewis, Mitchell
700 1 _aPhillips, Rob
773 0 _tProceedings of the National Academy of Sciences of the United States of America
_gvol. 116
_gno. 37
_gp. 18275-18284
856 4 0 _uhttps://doi.org/10.1073/pnas.1907869116
_zAvailable from publisher's website
999 _c30043785
_d30043785