000 02017 a2200601 4500
005 20250518050822.0
264 0 _c20190916
008 201909s 0 0 eng d
022 _a1879-3169
024 7 _a10.1016/j.toxlet.2019.06.010
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aChen, Biao
245 0 0 _aPrenatal nicotine exposure increases osteoarthritis susceptibility in male elderly offspring rats via low-function programming of the TGFβ signaling pathway.
_h[electronic resource]
260 _bToxicology letters
_cOct 2019
300 _a18-26 p.
_bdigital
500 _aPublication Type: Journal Article
650 0 4 _aAge Factors
650 0 4 _aAggrecans
_xmetabolism
650 0 4 _aAnimals
650 0 4 _aApoptosis
_xdrug effects
650 0 4 _aCaspase 3
_xmetabolism
650 0 4 _aCaspase 8
_xmetabolism
650 0 4 _aChondrocytes
_xdrug effects
650 0 4 _aChondrogenesis
_xdrug effects
650 0 4 _aCollagen Type II
_xmetabolism
650 0 4 _aFemale
650 0 4 _aGestational Age
650 0 4 _aInterleukin-1
_xmetabolism
650 0 4 _aInterleukin-6
_xmetabolism
650 0 4 _aJoints
_xdrug effects
650 0 4 _aMale
650 0 4 _aMaternal Exposure
650 0 4 _aMatrix Metalloproteinase 13
_xmetabolism
650 0 4 _aMatrix Metalloproteinase 3
_xmetabolism
650 0 4 _aNicotine
_xtoxicity
650 0 4 _aNicotinic Agonists
_xtoxicity
650 0 4 _aOsteoarthritis
_xchemically induced
650 0 4 _aPregnancy
650 0 4 _aPrenatal Exposure Delayed Effects
650 0 4 _aRats, Wistar
650 0 4 _aRisk Factors
650 0 4 _aSex Factors
650 0 4 _aSignal Transduction
650 0 4 _aTransforming Growth Factor beta
_xmetabolism
700 1 _aLu, Kai-Hang
700 1 _aNi, Qu-Bo
700 1 _aLi, Qing-Xian
700 1 _aGao, Hui
700 1 _aWang, Hui
700 1 _aChen, Liao-Bin
773 0 _tToxicology letters
_gvol. 314
_gp. 18-26
856 4 0 _uhttps://doi.org/10.1016/j.toxlet.2019.06.010
_zAvailable from publisher's website
999 _c29894970
_d29894970