000 02018 a2200553 4500
005 20250518045617.0
264 0 _c20200727
008 202007s 0 0 eng d
022 _a2451-9448
024 7 _a10.1016/j.chembiol.2019.06.003
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aSumi, Natalia J
245 0 0 _aDivergent Polypharmacology-Driven Cellular Activity of Structurally Similar Multi-Kinase Inhibitors through Cumulative Effects on Individual Targets.
_h[electronic resource]
260 _bCell chemical biology
_c09 2019
300 _a1240-1252.e11 p.
_bdigital
500 _aPublication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
650 0 4 _aAnilides
_xpharmacology
650 0 4 _aAntineoplastic Combined Chemotherapy Protocols
_xmetabolism
650 0 4 _aAurora Kinase B
_xmetabolism
650 0 4 _aCell Line, Tumor
650 0 4 _aDrug Discovery
650 0 4 _aHumans
650 0 4 _aLung Neoplasms
_xdrug therapy
650 0 4 _aMAP Kinase Kinase 1
_xmetabolism
650 0 4 _aMAP Kinase Kinase 2
_xmetabolism
650 0 4 _aOrganophosphates
_xpharmacology
650 0 4 _aPolypharmacology
650 0 4 _aProtein Kinase Inhibitors
_xchemistry
650 0 4 _aProtein-Tyrosine Kinases
_xmetabolism
650 0 4 _aPyridines
_xpharmacology
650 0 4 _aQuinazolines
_xpharmacology
650 0 4 _aQuinolines
_xpharmacology
650 0 4 _aSystems Analysis
700 1 _aCtortecka, Claudia
700 1 _aHu, Qianqian
700 1 _aBryant, Annamarie T
700 1 _aFang, Bin
700 1 _aRemsing Rix, Lily L
700 1 _aAyaz, Muhammad
700 1 _aKinose, Fumi
700 1 _aWelsh, Eric A
700 1 _aEschrich, Steven A
700 1 _aLawrence, Harshani R
700 1 _aKoomen, John M
700 1 _aHaura, Eric B
700 1 _aRix, Uwe
773 0 _tCell chemical biology
_gvol. 26
_gno. 9
_gp. 1240-1252.e11
856 4 0 _uhttps://doi.org/10.1016/j.chembiol.2019.06.003
_zAvailable from publisher's website
999 _c29853635
_d29853635