000 02854 a2200901 4500
005 20250518044520.0
264 0 _c20190926
008 201909s 0 0 eng d
022 _a1476-4687
024 7 _a10.1038/s41586-019-1315-z
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aJohnson, Eachan O
245 0 0 _aLarge-scale chemical-genetics yields new M. tuberculosis inhibitor classes.
_h[electronic resource]
260 _bNature
_c07 2019
300 _a72-78 p.
_bdigital
500 _aPublication Type: Journal Article
650 0 4 _aAntitubercular Agents
_xclassification
650 0 4 _aDNA Gyrase
_xmetabolism
650 0 4 _aDrug Discovery
_xmethods
650 0 4 _aDrug Resistance, Microbial
650 0 4 _aFolic Acid
_xbiosynthesis
650 0 4 _aGene Deletion
650 0 4 _aMicrobial Sensitivity Tests
_xmethods
650 0 4 _aMolecular Targeted Therapy
650 0 4 _aMycobacterium tuberculosis
_xcytology
650 0 4 _aMycolic Acids
_xmetabolism
650 0 4 _aReproducibility of Results
650 0 4 _aSmall Molecule Libraries
_xclassification
650 0 4 _aSubstrate Specificity
650 0 4 _aTopoisomerase II Inhibitors
_xisolation & purification
650 0 4 _aTryptophan
_xbiosynthesis
650 0 4 _aTuberculosis
_xdrug therapy
700 1 _aLaVerriere, Emily
700 1 _aOffice, Emma
700 1 _aStanley, Mary
700 1 _aMeyer, Elisabeth
700 1 _aKawate, Tomohiko
700 1 _aGomez, James E
700 1 _aAudette, Rebecca E
700 1 _aBandyopadhyay, Nirmalya
700 1 _aBetancourt, Natalia
700 1 _aDelano, Kayla
700 1 _aDa Silva, Israel
700 1 _aDavis, Joshua
700 1 _aGallo, Christina
700 1 _aGardner, Michelle
700 1 _aGolas, Aaron J
700 1 _aGuinn, Kristine M
700 1 _aKennedy, Sofia
700 1 _aKorn, Rebecca
700 1 _aMcConnell, Jennifer A
700 1 _aMoss, Caitlin E
700 1 _aMurphy, Kenan C
700 1 _aNietupski, Raymond M
700 1 _aPapavinasasundaram, Kadamba G
700 1 _aPinkham, Jessica T
700 1 _aPino, Paula A
700 1 _aProulx, Megan K
700 1 _aRuecker, Nadine
700 1 _aSong, Naomi
700 1 _aThompson, Matthew
700 1 _aTrujillo, Carolina
700 1 _aWakabayashi, Shoko
700 1 _aWallach, Joshua B
700 1 _aWatson, Christopher
700 1 _aIoerger, Thomas R
700 1 _aLander, Eric S
700 1 _aHubbard, Brian K
700 1 _aSerrano-Wu, Michael H
700 1 _aEhrt, Sabine
700 1 _aFitzgerald, Michael
700 1 _aRubin, Eric J
700 1 _aSassetti, Christopher M
700 1 _aSchnappinger, Dirk
700 1 _aHung, Deborah T
773 0 _tNature
_gvol. 571
_gno. 7763
_gp. 72-78
856 4 0 _uhttps://doi.org/10.1038/s41586-019-1315-z
_zAvailable from publisher's website
999 _c29816379
_d29816379