000 01738 a2200493 4500
005 20250518042837.0
264 0 _c20190624
008 201906s 0 0 eng d
022 _a2041-1723
024 7 _a10.1038/s41467-019-10363-1
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aBirkinshaw, Richard W
245 0 0 _aStructures of BCL-2 in complex with venetoclax reveal the molecular basis of resistance mutations.
_h[electronic resource]
260 _bNature communications
_c06 2019
300 _a2385 p.
_bdigital
500 _aPublication Type: Journal Article; Research Support, Non-U.S. Gov't
650 0 4 _aAntineoplastic Agents
_xmetabolism
650 0 4 _aBridged Bicyclo Compounds, Heterocyclic
_xmetabolism
650 0 4 _aCrystallization
650 0 4 _aCrystallography, X-Ray
650 0 4 _aDrug Resistance, Neoplasm
_xgenetics
650 0 4 _aHumans
650 0 4 _aLeukemia, Lymphocytic, Chronic, B-Cell
_xdrug therapy
650 0 4 _aMutation
650 0 4 _aProtein Binding
650 0 4 _aProto-Oncogene Proteins c-bcl-2
_xantagonists & inhibitors
650 0 4 _aSulfonamides
_xmetabolism
650 0 4 _aSurface Plasmon Resonance
700 1 _aGong, Jia-Nan
700 1 _aLuo, Cindy S
700 1 _aLio, Daisy
700 1 _aWhite, Christine A
700 1 _aAnderson, Mary Ann
700 1 _aBlombery, Piers
700 1 _aLessene, Guillaume
700 1 _aMajewski, Ian J
700 1 _aThijssen, Rachel
700 1 _aRoberts, Andrew W
700 1 _aHuang, David C S
700 1 _aColman, Peter M
700 1 _aCzabotar, Peter E
773 0 _tNature communications
_gvol. 10
_gno. 1
_gp. 2385
856 4 0 _uhttps://doi.org/10.1038/s41467-019-10363-1
_zAvailable from publisher's website
999 _c29760753
_d29760753