000			02149 a2200637 4500
005			20250518041126.0
264		0	_c20191218
008			201912s 0 0 eng d
022			_a2352-3964
024	7		_a10.1016/j.ebiom.2019.05.011 _2doi
040			_aNLM _beng _cNLM
100	1		_aZhou, Zhuan
245	0	0	_aA novel small-molecule antagonizes PRMT5-mediated KLF4 methylation for targeted therapy. _h[electronic resource]
260			_bEBioMedicine _cJun 2019
300			_a98-111 p. _bdigital
500			_aPublication Type: Journal Article
650	0	4	_aAnimals
650	0	4	_aAntineoplastic Agents _xpharmacology
650	0	4	_aCell Line
650	0	4	_aCell Line, Tumor
650	0	4	_aCell Survival _xdrug effects
650	0	4	_aDNA Damage
650	0	4	_aDNA Methylation _xdrug effects
650	0	4	_aDose-Response Relationship, Drug
650	0	4	_aDrug Discovery
650	0	4	_aEnzyme Inhibitors _xchemistry
650	0	4	_aEpigenesis, Genetic _xdrug effects
650	0	4	_aFemale
650	0	4	_aGene Expression Regulation, Neoplastic _xdrug effects
650	0	4	_aHumans
650	0	4	_aImmunohistochemistry
650	0	4	_aKruppel-Like Factor 4
650	0	4	_aKruppel-Like Transcription Factors _xgenetics
650	0	4	_aMice
650	0	4	_aModels, Molecular
650	0	4	_aMolecular Conformation
650	0	4	_aMolecular Targeted Therapy
650	0	4	_aNeoplastic Stem Cells _xmetabolism
650	0	4	_aProtein-Arginine N-Methyltransferases _xantagonists & inhibitors
650	0	4	_aRecombinant Fusion Proteins
650	0	4	_aStructure-Activity Relationship
650	0	4	_aSubstrate Specificity
650	0	4	_aTriple Negative Breast Neoplasms _xgenetics
650	0	4	_aXenograft Model Antitumor Assays
700	1		_aFeng, Zhiwei
700	1		_aHu, Dong
700	1		_aYang, Peng
700	1		_aGur, Mert
700	1		_aBahar, Ivet
700	1		_aCristofanilli, Massimo
700	1		_aGradishar, William J
700	1		_aXie, Xiang-Qun
700	1		_aWan, Yong
773	0		_tEBioMedicine _gvol. 44 _gp. 98-111
856	4	0	_uhttps://doi.org/10.1016/j.ebiom.2019.05.011 _zAvailable from publisher's website
999			_c29702862 _d29702862