000			02160 a2200637 4500
005			20250518032426.0
264		0	_c20191230
008			201912s 0 0 eng d
022			_a1521-0103
024	7		_a10.1124/jpet.119.257311 _2doi
040			_aNLM _beng _cNLM
100	1		_aBegg, Malcolm
245	0	0	_aTranslation of Inhaled Drug Optimization Strategies into Clinical Pharmacokinetics and Pharmacodynamics Using GSK2292767A, a Novel Inhaled Phosphoinositide 3-Kinase _h[electronic resource]
260			_bThe Journal of pharmacology and experimental therapeutics _c06 2019
300			_a443-453 p. _bdigital
500			_aPublication Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
650	0	4	_aAdministration, Inhalation
650	0	4	_aAdult
650	0	4	_aAnimals
650	0	4	_aBronchoalveolar Lavage
650	0	4	_aEosinophilia _xdrug therapy
650	0	4	_aFemale
650	0	4	_aHumans
650	0	4	_aIndazoles _xadministration & dosage
650	0	4	_aLung _xmetabolism
650	0	4	_aMale
650	0	4	_aMice
650	0	4	_aMiddle Aged
650	0	4	_aPermeability
650	0	4	_aPhosphoinositide-3 Kinase Inhibitors _xadministration & dosage
650	0	4	_aSafety
650	0	4	_aSolubility
650	0	4	_aSputum _xdrug effects
650	0	4	_aSulfonamides _xadministration & dosage
650	0	4	_aTranslational Research, Biomedical
700	1		_aEdwards, Chris D
700	1		_aHamblin, J Nicole
700	1		_aPefani, Eleni
700	1		_aWilson, Robert
700	1		_aGilbert, Jane
700	1		_aVitulli, Giovanni
700	1		_aMallett, David
700	1		_aMorrell, Josie
700	1		_aHingle, Martin I
700	1		_aUddin, Sorif
700	1		_aEhtesham, Filzah
700	1		_aMarotti, Miriam
700	1		_aHarrell, Andrew
700	1		_aNewman, Carla F
700	1		_aFernando, Disala
700	1		_aClark, Jonathan
700	1		_aCahn, Anthony
700	1		_aHessel, Edith M
773	0		_tThe Journal of pharmacology and experimental therapeutics _gvol. 369 _gno. 3 _gp. 443-453
856	4	0	_uhttps://doi.org/10.1124/jpet.119.257311 _zAvailable from publisher's website
999			_c29545338 _d29545338