000 01554 a2200445 4500
005 20250518024540.0
264 0 _c20191218
008 201912s 0 0 eng d
022 _a1554-8937
024 7 _a10.1021/acschembio.8b01094
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aTinworth, Christopher P
245 0 0 _aPROTAC-Mediated Degradation of Bruton's Tyrosine Kinase Is Inhibited by Covalent Binding.
_h[electronic resource]
260 _bACS chemical biology
_c03 2019
300 _a342-347 p.
_bdigital
500 _aPublication Type: Journal Article; Research Support, Non-U.S. Gov't
650 0 4 _aAdenine
_xanalogs & derivatives
650 0 4 _aAgammaglobulinaemia Tyrosine Kinase
_xmetabolism
650 0 4 _aInhibitor of Apoptosis Proteins
_xmetabolism
650 0 4 _aPiperidines
650 0 4 _aProtein Binding
650 0 4 _aProtein Kinase Inhibitors
_xchemistry
650 0 4 _aProteolysis
650 0 4 _aPyrazoles
_xchemistry
650 0 4 _aPyrimidines
_xchemistry
650 0 4 _aUbiquitin-Protein Ligases
_xmetabolism
700 1 _aLithgow, Hannah
700 1 _aDittus, Lars
700 1 _aBassi, Zuni I
700 1 _aHughes, Sophie E
700 1 _aMuelbaier, Marcel
700 1 _aDai, Han
700 1 _aSmith, Ian E D
700 1 _aKerr, William J
700 1 _aBurley, Glenn A
700 1 _aBantscheff, Marcus
700 1 _aHarling, John D
773 0 _tACS chemical biology
_gvol. 14
_gno. 3
_gp. 342-347
856 4 0 _uhttps://doi.org/10.1021/acschembio.8b01094
_zAvailable from publisher's website
999 _c29414739
_d29414739