000 01671 a2200481 4500
005 20250518012112.0
264 0 _c20181224
008 201812s 0 0 eng d
022 _a1347-5223
024 7 _a10.1248/cpb.c18-00571
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aMorishita, Ko
245 0 0 _a2-Acyl-3-carboxyl-tetrahydroisoquinoline Derivatives: Mixed-Type PTP1B Inhibitors without PPARγ Activation.
_h[electronic resource]
260 _bChemical & pharmaceutical bulletin
_c2018
300 _a1131-1152 p.
_bdigital
500 _aPublication Type: Journal Article
650 0 4 _aAnimals
650 0 4 _aDiabetes Mellitus, Experimental
_xdrug therapy
650 0 4 _aDose-Response Relationship, Drug
650 0 4 _aEnzyme Inhibitors
_xblood
650 0 4 _aHumans
650 0 4 _aHypoglycemic Agents
_xblood
650 0 4 _aMale
650 0 4 _aMice
650 0 4 _aMice, Inbred Strains
650 0 4 _aMolecular Docking Simulation
650 0 4 _aMolecular Structure
650 0 4 _aPPAR gamma
_xmetabolism
650 0 4 _aProtein Tyrosine Phosphatase, Non-Receptor Type 1
_xantagonists & inhibitors
650 0 4 _aRats
650 0 4 _aRats, Sprague-Dawley
650 0 4 _aStructure-Activity Relationship
650 0 4 _aTetrahydroisoquinolines
_xblood
700 1 _aShoji, Yoshimichi
700 1 _aFukui, Masaki
700 1 _aIto, Yuma
700 1 _aKitao, Tatsuya
700 1 _aOzawa, Shin-Ichiro
700 1 _aHirono, Shuichi
700 1 _aShirahase, Hiroaki
773 0 _tChemical & pharmaceutical bulletin
_gvol. 66
_gno. 12
_gp. 1131-1152
856 4 0 _uhttps://doi.org/10.1248/cpb.c18-00571
_zAvailable from publisher's website
999 _c29118542
_d29118542