| 000 | 01647 a2200481 4500 | ||
|---|---|---|---|
| 005 | 20250518001644.0 | ||
| 264 | 0 | _c20191003 | |
| 008 | 201910s 0 0 eng d | ||
| 022 | _a2161-5063 | ||
| 024 | 7 |
_a10.1021/acssynbio.8b00188 _2doi |
|
| 040 |
_aNLM _beng _cNLM |
||
| 100 | 1 | _aImada, Takashi | |
| 245 | 0 | 0 |
_aA Highly Bioactive Lys-Deficient IFN Leads to a Site-Specific Di-PEGylated IFN with Equivalent Bioactivity to That of Unmodified IFN-α2b. _h[electronic resource] |
| 260 |
_bACS synthetic biology _c11 2018 |
||
| 300 |
_a2537-2546 p. _bdigital |
||
| 500 | _aPublication Type: Journal Article; Research Support, Non-U.S. Gov't | ||
| 650 | 0 | 4 | _aAnimals |
| 650 | 0 | 4 |
_aAntiviral Agents _xblood |
| 650 | 0 | 4 | _aDirected Molecular Evolution |
| 650 | 0 | 4 | _aHumans |
| 650 | 0 | 4 | _aInterferon alpha-2 |
| 650 | 0 | 4 |
_aInterferon-alpha _xchemistry |
| 650 | 0 | 4 |
_aLysine _xdeficiency |
| 650 | 0 | 4 | _aMice |
| 650 | 0 | 4 | _aMutagenesis, Site-Directed |
| 650 | 0 | 4 |
_aPolyethylene Glycols _xchemistry |
| 650 | 0 | 4 | _aProtein Stability |
| 650 | 0 | 4 |
_aRecombinant Proteins _xbiosynthesis |
| 700 | 1 | _aMoriya, Koji | |
| 700 | 1 | _aUchiyama, Masahiko | |
| 700 | 1 | _aInukai, Naoto | |
| 700 | 1 | _aHitotsuyanagi, Mitsuhiro | |
| 700 | 1 | _aMasuda, Akiko | |
| 700 | 1 | _aSuzuki, Takehiro | |
| 700 | 1 | _aAyukawa, Shotaro | |
| 700 | 1 | _aTagawa, Yo-Ichi | |
| 700 | 1 | _aDohmae, Naoshi | |
| 700 | 1 | _aKohara, Michinori | |
| 700 | 1 | _aYamamura, Masayuki | |
| 700 | 1 | _aKiga, Daisuke | |
| 773 | 0 |
_tACS synthetic biology _gvol. 7 _gno. 11 _gp. 2537-2546 |
|
| 856 | 4 | 0 |
_uhttps://doi.org/10.1021/acssynbio.8b00188 _zAvailable from publisher's website |
| 999 |
_c28896524 _d28896524 |
||