| 000 | 02606 a2200745 4500 | ||
|---|---|---|---|
| 005 | 20250517232958.0 | ||
| 264 | 0 | _c20191007 | |
| 008 | 201910s 0 0 eng d | ||
| 022 | _a1520-4804 | ||
| 024 | 7 |
_a10.1021/acs.jmedchem.8b00917 _2doi |
|
| 040 |
_aNLM _beng _cNLM |
||
| 100 | 1 | _aFensome, Andrew | |
| 245 | 0 | 0 |
_aDual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of (( S)-2,2-Difluorocyclopropyl)((1 R,5 S)-3-(2-((1-methyl-1 H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700841). _h[electronic resource] |
| 260 |
_bJournal of medicinal chemistry _c10 2018 |
||
| 300 |
_a8597-8612 p. _bdigital |
||
| 500 | _aPublication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. | ||
| 650 | 0 | 4 | _aAnimals |
| 650 | 0 | 4 |
_aAntitubercular Agents _xpharmacology |
| 650 | 0 | 4 |
_aArthritis, Experimental _xchemically induced |
| 650 | 0 | 4 | _aFemale |
| 650 | 0 | 4 |
_aJanus Kinase 1 _xantagonists & inhibitors |
| 650 | 0 | 4 | _aMolecular Structure |
| 650 | 0 | 4 |
_aMycobacterium tuberculosis _xdrug effects |
| 650 | 0 | 4 |
_aProtein Kinase Inhibitors _xpharmacology |
| 650 | 0 | 4 |
_aPyrazoles _xpharmacology |
| 650 | 0 | 4 |
_aPyrimidines _xpharmacology |
| 650 | 0 | 4 | _aRats |
| 650 | 0 | 4 | _aRats, Inbred Lew |
| 650 | 0 | 4 |
_aTYK2 Kinase _xantagonists & inhibitors |
| 650 | 0 | 4 |
_aTuberculosis _xcomplications |
| 700 | 1 | _aAmbler, Catherine M | |
| 700 | 1 | _aArnold, Eric | |
| 700 | 1 | _aBanker, Mary Ellen | |
| 700 | 1 | _aBrown, Matthew F | |
| 700 | 1 | _aChrencik, Jill | |
| 700 | 1 | _aClark, James D | |
| 700 | 1 | _aDowty, Martin E | |
| 700 | 1 | _aEfremov, Ivan V | |
| 700 | 1 | _aFlick, Andrew | |
| 700 | 1 | _aGerstenberger, Brian S | |
| 700 | 1 | _aGopalsamy, Ariamala | |
| 700 | 1 | _aHayward, Matthew M | |
| 700 | 1 | _aHegen, Martin | |
| 700 | 1 | _aHollingshead, Brett D | |
| 700 | 1 | _aJussif, Jason | |
| 700 | 1 | _aKnafels, John D | |
| 700 | 1 | _aLimburg, David C | |
| 700 | 1 | _aLin, David | |
| 700 | 1 | _aLin, Tsung H | |
| 700 | 1 | _aPierce, Betsy S | |
| 700 | 1 | _aSaiah, Eddine | |
| 700 | 1 | _aSharma, Raman | |
| 700 | 1 | _aSymanowicz, Peter T | |
| 700 | 1 | _aTelliez, Jean-Baptiste | |
| 700 | 1 | _aTrujillo, John I | |
| 700 | 1 | _aVajdos, Felix F | |
| 700 | 1 | _aVincent, Fabien | |
| 700 | 1 | _aWan, Zhao-Kui | |
| 700 | 1 | _aXing, Li | |
| 700 | 1 | _aYang, Xiaojing | |
| 700 | 1 | _aYang, Xin | |
| 700 | 1 | _aZhang, Liying | |
| 773 | 0 |
_tJournal of medicinal chemistry _gvol. 61 _gno. 19 _gp. 8597-8612 |
|
| 856 | 4 | 0 |
_uhttps://doi.org/10.1021/acs.jmedchem.8b00917 _zAvailable from publisher's website |
| 999 |
_c28735940 _d28735940 |
||