| 000 | 02645 a2200757 4500 | ||
|---|---|---|---|
| 005 | 20250517232726.0 | ||
| 264 | 0 | _c20190507 | |
| 008 | 201905s 0 0 eng d | ||
| 022 | _a1476-4679 | ||
| 024 | 7 |
_a10.1038/s41556-018-0169-1 _2doi |
|
| 040 |
_aNLM _beng _cNLM |
||
| 100 | 1 | _aNichols, Robert J | |
| 245 | 0 | 0 |
_aRAS nucleotide cycling underlies the SHP2 phosphatase dependence of mutant BRAF-, NF1- and RAS-driven cancers. _h[electronic resource] |
| 260 |
_bNature cell biology _c09 2018 |
||
| 300 |
_a1064-1073 p. _bdigital |
||
| 500 | _aPublication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't | ||
| 650 | 0 | 4 | _aAnimals |
| 650 | 0 | 4 |
_aAntineoplastic Agents _xpharmacology |
| 650 | 0 | 4 |
_aBiomarkers, Tumor _xgenetics |
| 650 | 0 | 4 | _aCell Line, Tumor |
| 650 | 0 | 4 |
_aEnzyme Inhibitors _xpharmacology |
| 650 | 0 | 4 |
_aExtracellular Signal-Regulated MAP Kinases _xmetabolism |
| 650 | 0 | 4 | _aGenetic Predisposition to Disease |
| 650 | 0 | 4 |
_aGuanosine Triphosphate _xmetabolism |
| 650 | 0 | 4 | _aHEK293 Cells |
| 650 | 0 | 4 | _aHumans |
| 650 | 0 | 4 | _aMice, Inbred BALB C |
| 650 | 0 | 4 | _aMice, Nude |
| 650 | 0 | 4 |
_aMitogen-Activated Protein Kinase Kinases _xmetabolism |
| 650 | 0 | 4 | _aMutation |
| 650 | 0 | 4 |
_aNeoplasms _xdrug therapy |
| 650 | 0 | 4 |
_aNeurofibromin 1 _xgenetics |
| 650 | 0 | 4 | _aPhenotype |
| 650 | 0 | 4 |
_aProtein Tyrosine Phosphatase, Non-Receptor Type 11 _xantagonists & inhibitors |
| 650 | 0 | 4 |
_aProto-Oncogene Proteins B-raf _xgenetics |
| 650 | 0 | 4 |
_aProto-Oncogene Proteins p21(ras) _xgenetics |
| 650 | 0 | 4 |
_aSOS1 Protein _xmetabolism |
| 650 | 0 | 4 | _aSignal Transduction |
| 650 | 0 | 4 |
_aTumor Burden _xdrug effects |
| 650 | 0 | 4 | _aXenograft Model Antitumor Assays |
| 650 | 0 | 4 |
_araf Kinases _xmetabolism |
| 700 | 1 | _aHaderk, Franziska | |
| 700 | 1 | _aStahlhut, Carlos | |
| 700 | 1 | _aSchulze, Christopher J | |
| 700 | 1 | _aHemmati, Golzar | |
| 700 | 1 | _aWildes, David | |
| 700 | 1 | _aTzitzilonis, Christos | |
| 700 | 1 | _aMordec, Kasia | |
| 700 | 1 | _aMarquez, Abby | |
| 700 | 1 | _aRomero, Jason | |
| 700 | 1 | _aHsieh, Tientien | |
| 700 | 1 | _aZaman, Aubhishek | |
| 700 | 1 | _aOlivas, Victor | |
| 700 | 1 | _aMcCoach, Caroline | |
| 700 | 1 | _aBlakely, Collin M | |
| 700 | 1 | _aWang, Zhengping | |
| 700 | 1 | _aKiss, Gert | |
| 700 | 1 | _aKoltun, Elena S | |
| 700 | 1 | _aGill, Adrian L | |
| 700 | 1 | _aSingh, Mallika | |
| 700 | 1 | _aGoldsmith, Mark A | |
| 700 | 1 | _aSmith, Jacqueline A M | |
| 700 | 1 | _aBivona, Trever G | |
| 773 | 0 |
_tNature cell biology _gvol. 20 _gno. 9 _gp. 1064-1073 |
|
| 856 | 4 | 0 |
_uhttps://doi.org/10.1038/s41556-018-0169-1 _zAvailable from publisher's website |
| 999 |
_c28726980 _d28726980 |
||