| 000 | 02572 a2200805 4500 | ||
|---|---|---|---|
| 005 | 20250517224255.0 | ||
| 264 | 0 | _c20181211 | |
| 008 | 201812s 0 0 eng d | ||
| 022 | _a1476-4687 | ||
| 024 | 7 |
_a10.1038/s41586-018-0251-7 _2doi |
|
| 040 |
_aNLM _beng _cNLM |
||
| 100 | 1 | _aIntlekofer, Andrew M | |
| 245 | 0 | 0 |
_aAcquired resistance to IDH inhibition through trans or cis dimer-interface mutations. _h[electronic resource] |
| 260 |
_bNature _c07 2018 |
||
| 300 |
_a125-129 p. _bdigital |
||
| 500 | _aPublication Type: Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't | ||
| 650 | 0 | 4 | _aAlleles |
| 650 | 0 | 4 |
_aAllosteric Site _xdrug effects |
| 650 | 0 | 4 |
_aAminopyridines _xchemistry |
| 650 | 0 | 4 | _aAnimals |
| 650 | 0 | 4 | _aClinical Trials, Phase I as Topic |
| 650 | 0 | 4 | _aClinical Trials, Phase II as Topic |
| 650 | 0 | 4 | _aDisease Progression |
| 650 | 0 | 4 |
_aDrug Resistance, Neoplasm _xdrug effects |
| 650 | 0 | 4 |
_aEnzyme Inhibitors _xchemistry |
| 650 | 0 | 4 | _aFemale |
| 650 | 0 | 4 |
_aGlutamine _xgenetics |
| 650 | 0 | 4 |
_aGlutarates _xblood |
| 650 | 0 | 4 | _aHEK293 Cells |
| 650 | 0 | 4 | _aHumans |
| 650 | 0 | 4 |
_aIsocitrate Dehydrogenase _xantagonists & inhibitors |
| 650 | 0 | 4 |
_aIsoleucine _xgenetics |
| 650 | 0 | 4 |
_aLeukemia, Myeloid, Acute _xblood |
| 650 | 0 | 4 | _aMice |
| 650 | 0 | 4 | _aMice, Inbred C57BL |
| 650 | 0 | 4 | _aModels, Molecular |
| 650 | 0 | 4 |
_aMutant Proteins _xantagonists & inhibitors |
| 650 | 0 | 4 | _aMutation |
| 650 | 0 | 4 |
_aProtein Multimerization _xgenetics |
| 650 | 0 | 4 |
_aTriazines _xchemistry |
| 700 | 1 | _aShih, Alan H | |
| 700 | 1 | _aWang, Bo | |
| 700 | 1 | _aNazir, Abbas | |
| 700 | 1 | _aRustenburg, Ariën S | |
| 700 | 1 | _aAlbanese, Steven K | |
| 700 | 1 | _aPatel, Minal | |
| 700 | 1 | _aFamulare, Christopher | |
| 700 | 1 | _aCorrea, Fabian M | |
| 700 | 1 | _aTakemoto, Naofumi | |
| 700 | 1 | _aDurani, Vidushi | |
| 700 | 1 | _aLiu, Hui | |
| 700 | 1 | _aTaylor, Justin | |
| 700 | 1 | _aFarnoud, Noushin | |
| 700 | 1 | _aPapaemmanuil, Elli | |
| 700 | 1 | _aCross, Justin R | |
| 700 | 1 | _aTallman, Martin S | |
| 700 | 1 | _aArcila, Maria E | |
| 700 | 1 | _aRoshal, Mikhail | |
| 700 | 1 | _aPetsko, Gregory A | |
| 700 | 1 | _aWu, Bin | |
| 700 | 1 | _aChoe, Sung | |
| 700 | 1 | _aKonteatis, Zenon D | |
| 700 | 1 | _aBiller, Scott A | |
| 700 | 1 | _aChodera, John D | |
| 700 | 1 | _aThompson, Craig B | |
| 700 | 1 | _aLevine, Ross L | |
| 700 | 1 | _aStein, Eytan M | |
| 773 | 0 |
_tNature _gvol. 559 _gno. 7712 _gp. 125-129 |
|
| 856 | 4 | 0 |
_uhttps://doi.org/10.1038/s41586-018-0251-7 _zAvailable from publisher's website |
| 999 |
_c28577369 _d28577369 |
||