000			02161 a2200589 4500
005			20250517213549.0
264		0	_c20180801
008			201808s 0 0 eng d
022			_a1932-6203
024	7		_a10.1371/journal.pone.0196352 _2doi
040			_aNLM _beng _cNLM
100	1		_aSpeer, Esther M
245	0	0	_aPentoxifylline, dexamethasone and azithromycin demonstrate distinct age-dependent and synergistic inhibition of TLR- and inflammasome-mediated cytokine production in human newborn and adult blood in vitro. _h[electronic resource]
260			_bPloS one _c2018
300			_ae0196352 p. _bdigital
500			_aPublication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
650	0	4	_aAdolescent
650	0	4	_aAdult
650	0	4	_aAging _xblood
650	0	4	_aAnti-Inflammatory Agents _xpharmacology
650	0	4	_aAzithromycin _xpharmacology
650	0	4	_aCaspase 1 _xmetabolism
650	0	4	_aCytokines _xbiosynthesis
650	0	4	_aDexamethasone _xpharmacology
650	0	4	_aDrug Synergism
650	0	4	_aDual Specificity Phosphatase 1 _xgenetics
650	0	4	_aEnzyme Activation _xdrug effects
650	0	4	_aFemale
650	0	4	_aGene Expression Regulation _xdrug effects
650	0	4	_aHumans
650	0	4	_aInfant, Newborn
650	0	4	_aInflammasomes _xmetabolism
650	0	4	_aMiddle Aged
650	0	4	_aMitogen-Activated Protein Kinases _xmetabolism
650	0	4	_aMonocytes _xdrug effects
650	0	4	_aNF-kappa B _xmetabolism
650	0	4	_aPentoxifylline _xpharmacology
650	0	4	_aPregnancy
650	0	4	_aRNA, Messenger _xgenetics
650	0	4	_aSignal Transduction _xdrug effects
650	0	4	_aToll-Like Receptors _xmetabolism
650	0	4	_aYoung Adult
700	1		_aDowling, David J
700	1		_aXu, Jianjin
700	1		_aOzog, Lukasz S
700	1		_aMathew, Jaime A
700	1		_aChander, Avinash
700	1		_aYin, Donglei
700	1		_aLevy, Ofer
773	0		_tPloS one _gvol. 13 _gno. 5 _gp. e0196352
856	4	0	_uhttps://doi.org/10.1371/journal.pone.0196352 _zAvailable from publisher's website
999			_c28346123 _d28346123