000 02552 a2200685 4500
005 20250517210516.0
264 0 _c20180829
008 201808s 0 0 eng d
022 _a1091-6490
024 7 _a10.1073/pnas.1801213115
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aChen, Shuliang
245 0 0 _aSAMHD1 suppresses innate immune responses to viral infections and inflammatory stimuli by inhibiting the NF-κB and interferon pathways.
_h[electronic resource]
260 _bProceedings of the National Academy of Sciences of the United States of America
_c04 2018
300 _aE3798-E3807 p.
_bdigital
500 _aPublication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
650 0 4 _aAnimals
650 0 4 _aCells, Cultured
650 0 4 _aDown-Regulation
650 0 4 _aGene Expression Regulation
_xdrug effects
650 0 4 _aGene Silencing
650 0 4 _aHEK293 Cells
650 0 4 _aHIV
_xphysiology
650 0 4 _aHumans
650 0 4 _aI-kappa B Kinase
_xantagonists & inhibitors
650 0 4 _aImmunity, Innate
650 0 4 _aInflammation
_ximmunology
650 0 4 _aInterferon Regulatory Factor-7
_xantagonists & inhibitors
650 0 4 _aInterferon-alpha
_xbiosynthesis
650 0 4 _aMacrophages
_ximmunology
650 0 4 _aMale
650 0 4 _aMice
650 0 4 _aNF-KappaB Inhibitor alpha
_xmetabolism
650 0 4 _aNF-kappa B
_xmetabolism
650 0 4 _aPhosphorylation
650 0 4 _aProtein Processing, Post-Translational
650 0 4 _aRecombinant Proteins
_ximmunology
650 0 4 _aSAM Domain and HD Domain-Containing Protein 1
_xphysiology
650 0 4 _aSendai virus
_xphysiology
650 0 4 _aSignal Transduction
_ximmunology
650 0 4 _aTHP-1 Cells
650 0 4 _aVirus Diseases
_ximmunology
700 1 _aBonifati, Serena
700 1 _aQin, Zhihua
700 1 _aSt Gelais, Corine
700 1 _aKodigepalli, Karthik M
700 1 _aBarrett, Bradley S
700 1 _aKim, Sun Hee
700 1 _aAntonucci, Jenna M
700 1 _aLadner, Katherine J
700 1 _aBuzovetsky, Olga
700 1 _aKnecht, Kirsten M
700 1 _aXiong, Yong
700 1 _aYount, Jacob S
700 1 _aGuttridge, Denis C
700 1 _aSantiago, Mario L
700 1 _aWu, Li
773 0 _tProceedings of the National Academy of Sciences of the United States of America
_gvol. 115
_gno. 16
_gp. E3798-E3807
856 4 0 _uhttps://doi.org/10.1073/pnas.1801213115
_zAvailable from publisher's website
999 _c28243323
_d28243323