000 02081 a2200577 4500
005 20250517194920.0
264 0 _c20180222
008 201802s 0 0 eng d
022 _a2041-1723
024 7 _a10.1038/s41467-017-02252-2
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aKrishnan, Navasona
245 0 0 _aHarnessing insulin- and leptin-induced oxidation of PTP1B for therapeutic development.
_h[electronic resource]
260 _bNature communications
_c01 2018
300 _a283 p.
_bdigital
500 _aPublication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
650 0 4 _aAmino Acid Sequence
650 0 4 _aAnti-Obesity Agents
_xchemistry
650 0 4 _aBenzophenanthridines
_xchemistry
650 0 4 _aBinding Sites
650 0 4 _aCloning, Molecular
650 0 4 _aCrystallography, X-Ray
650 0 4 _aEnzyme Inhibitors
_xchemistry
650 0 4 _aEscherichia coli
_xgenetics
650 0 4 _aGene Expression
650 0 4 _aHumans
650 0 4 _aHypoglycemic Agents
_xchemistry
650 0 4 _aInsulin
_xchemistry
650 0 4 _aIsoquinolines
_xchemistry
650 0 4 _aLeptin
_xchemistry
650 0 4 _aLevamisole
_xchemistry
650 0 4 _aMolecular Docking Simulation
650 0 4 _aOxidation-Reduction
650 0 4 _aProtein Binding
650 0 4 _aProtein Interaction Domains and Motifs
650 0 4 _aProtein Structure, Secondary
650 0 4 _aProtein Tyrosine Phosphatase, Non-Receptor Type 1
_xantagonists & inhibitors
650 0 4 _aRecombinant Proteins
_xchemistry
650 0 4 _aSingle-Chain Antibodies
_xchemistry
650 0 4 _aSmall Molecule Libraries
_xchemistry
700 1 _aBonham, Christopher A
700 1 _aRus, Ioana A
700 1 _aShrestha, Om Kumar
700 1 _aGauss, Carla M
700 1 _aHaque, Aftabul
700 1 _aTocilj, Ante
700 1 _aJoshua-Tor, Leemor
700 1 _aTonks, Nicholas K
773 0 _tNature communications
_gvol. 9
_gno. 1
_gp. 283
856 4 0 _uhttps://doi.org/10.1038/s41467-017-02252-2
_zAvailable from publisher's website
999 _c27994014
_d27994014